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Objective To observe the correlation between adipokines Omentin-1, adiponectin and bone mineral density in middle-aged women. Method 338 women who were admitted to our hospital from March 2017 to April 2018 were selected. According to the menopausal status, the menopausal/menopausal group (n=194) and the postmenopausal group (n=124) were divided. Multivariable-adjusted ANCOVA including age, BMI, waist circumference, smoking status, physical activity, adiponectin or Omentin-1 and hormone use was used to investigate potential relationships between the adipokines and BMD. Results Peri-/premenopausal women had higher BMD of lumbar vertebrae (0.89±0.09g/cm2), compared to postmenopausal women (0.69±0.08g/cm2) (P<0.05). In peri-/premenopausal women neither adiponectin nor Omentin-1 was significantly associated with BMD of lumbar vertebrae(P>0.05). In postmenopausal women, adiponectin was not associated with BMD of lumbar vertebrae(P>0.05). In postmenopausal women, Omentin-1 was significantly negatively correlated with lumbar spine BMD (P<0.05). Conclusion Our study provides evidence for circulating Omentin-1 levels have an inverse correlation with BMD at the lumbar spine in postmenopausal women. [ABSTRACT FROM AUTHOR]