Objective To investigate the prognostic values of three different staging schemes including the number of lymph node metastasis ( N stage), lymph node ratio ( LNR) and log odd of positive lymph nodes ( LODDS) in pancreatic cancer patients after RO resection. Methods The clinical and pathological data of 307 pm1ereatic cm1eer patients who 1mderwent RO resection at Cancer Hospital of Chinese Academy of Medical Sciences from January 2010 to December 2018 were retrospectively analyzed. Kaplan-Meier and Cox propm1ional hazard regression models were used to analyze the indepedent prognostic factors. The area under the receiver operator characteristic curve ( A UC) was used to compare the prognostic efficacy of different lymph node staging systems. Results The median survival was 24. 0 months, I-year, 3-year and 5-year- survival rates were 72.0%,, 35.5% and 24.0%, respectively. Multivariate analysis showed that CA 199, differentiation, T stage, adjuvant therapy, N stage, LNR stage, and LODDS stage were independent prognostic factors for pancreatic cancer patients after RO resection (P<0.05). The A.UC values of the I-year survival rate for N stage, LNR stage, and LODDS stage were 0.591, 0.592 and 0.609, respectively. The A.UC values of the 3-ycar survival rate for N stage, LNR stage, and LODDS stage were 0.585, 0.588 and 0.593, respectively. The AUC values of the 5-ye,u- survival rate for N stage, LNR stage,,md LODDS stage were 0.554, 0.557 and 0.589, respectively. The AUC values of the LODDS stage were the highest while the N stage were the lowest, but there was no significant difference among these three systems (P>0. 05). For all patients, the LODDS staging system was slightly better than the N and LNR staging systems, but the difference was not statistically significant ( P > 0. 05). For patients with NO stage, the LODDS staging system showed better prediction performance than the N stage and LNR staging systems ( P< 0.05). Conclusions The N stage, LNR stage,,md LODDS stage arc independent prognostic factors for pancreatic cancer patients after R0 resection. For patients without lymph node metastasis., LODDS staging system is superior to N and LNR staging systems in predicting prognosis. [ABSTRACT FROM AUTHOR]