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Copyright of Chinese Journal of Diabetes Mellitus is the property of Chinese Journal of Diabetes Mellitus and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Diabetes Mellitus is the property of Chinese Journal of Diabetes Mellitus and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

神经素4（NRG4）是一种新型脂肪因子, 其在能量平衡和糖脂代谢中发挥着重要的作 用。近年来, NRG4 与2 型糖尿病（T2DM）及冠心病的关系受到越来越多的关注。NRG4 有望成为 T2DM及冠心病发生发展风险的新型预测因子。该文就NRG4与T2DM及冠心病的关系进行综述。. [ABSTRACT FROM AUTHOR]

血糖波动是糖尿病研究的热点之一, 近年来其评价手段及评估参数得到不断丰富。但 目前大多数参数仍仅关注短期血糖波动的幅度, 而未体现血糖变化在时间尺度上的规律性, 因此, 寻 找能综合血糖波动幅度和时间序列上变化的参数是大家感兴趣的方向之一。短期和长期血糖波动与 糖尿病慢性并发症的相关性已有较多临床证据支持, 而基础机制的研究仍在不断完善中。血糖波动 异常除了通过氧化应激和慢性炎症等机制外, 尚通过表观遗传学改变导致血管损伤。此外, 随着新型 降糖药物的不断涌现, 其对血糖波动异常的改善程度也受到重视, 以期进一步延缓糖尿病慢性并发症 的发生发展。 [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Diabetes Mellitus is the property of Chinese Journal of Diabetes Mellitus and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The aim of the current study is to investigate whether 1, 5‐anhydroglucitol (1, 5‐AG), glycated albumin (GA) and GA to glycated hemoglobin A1c (HbA1c) ratio can be used for early identify fulminant type 1 diabetes mellitus (FT1DM) and type 1A diabetes mellitus (T1ADM). Methods From January 2007 to July 2018, 20 FT1DM patients and 47 newly diagnosed T1ADM patients (age and sex matched, HbA1c <8.7%) admitted to the Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People′s Hospital were included in this study. Then, the serum 1, 5‐AG, GA, and HbA1c of these patients were measured for analysis. The 1, 5‐AG, GA and GA/HbA1c ratio between FT1DM and T1ADM patients were compared by the t test and Mann‐Whitney U test. The receiver operating characteristic (ROC) curve was used to evaluate the efficacy of those indicators in identifying FT1DM and T1ADM with HbA1c <8.7%. Results The FT1DM patients had a decrease trend of 1, 5‐AG, although the GA increased slightly comparing with T1ADM patients, the differences was not statistically significant (both P>0.05). However, the GA/HbA1c ratio in FT1DM patients increased significantly than those in T1ADM patients (P=0.001). The optimal cut‐off points for 1, 5‐AG and GA identifing FT1DM and T1ADM were 6.2 μg/ml and 17.9%, with their sensitivity up to 95.0% and 90.0% respectively, while the specificity was only 31.9% and 34.0%, and the area under the curve (AUC) was 0.597 and 0.601, respectively. No difference was found in screening efficacy (P=0.972). As for GA/HbA1c ratio, the optimal cut‐off point was 3.187, with its sensitivity, specificity and AUC of 70.0%, 76.6%, and 0.769, respectively. Therefore, GA/HbA1c was clearly superior to 1, 5‐AG or GA alone. Conclusion GA/HbA1c ratio is a better indicator for early identification of FT1DM than 1, 5‐AG or GA. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Diabetes Mellitus is the property of Chinese Journal of Diabetes Mellitus and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Diabetes Mellitus is the property of Chinese Journal of Diabetes Mellitus and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To explore the relationship between serum serine protease inhibitor B1 (SerpinB1) and the risk of gestational diabetes mellitus (GDM). Methods A total of 328 pregnant women who were checked up in the clinic of Shengjing Hospital of China Medical University from 2016 to 2018 were divided into two groups according to GDM diagnostic criteria: normal (NC) group (n=155) and GDM group (n=173). The correlations between serum SerpinB1 level and glucose and lipid metabolism indexes were analyzed in 5-12 weeks, 13-23 weeks, 24-28 weeks and 29-37 weeks of pregnancy. The pregnant women who did not have GDM at 5-12 weeks of gestation but diagnosed GDM after 24 weeks of pregnancy were selected as GDM‑A group (n=18). The pregnant women who did not have GDM at 13-23 weeks of gestation but diagnosed GDM after 24 weeks of pregnancy were selected as GDM‑B group (n=26). Logistic regression was used to analyze the risk factors of GDM during pregnancy. Receiver operating characteristic (ROC) curve predicted the cut‑off value of serum SerpinB1 levels affecting the occurrence of GDM after 24 weeks of pregnancy. Results In the GDM group, the serum SerpinB1 level at 5-12 weeks gestation, 13-23 weeks gestation, 24-28 weeks gestation of pregnancy was significantly higher than that in the NC group (P<0.05). At 24-28 weeks of gestation, the level of serum SerpinB1 was positively correlated with LDL‑C(r=0.786, P<0.05) and negatively correlated with fasting insulin and HOMA‑IR(r=-0.724 and -0.680 respectively, P<0.05). After correcting the confounding factors such as gestational age, pre‑pregnant BMI, acanthosis nigricans and triglycerides, etc, serum SerpinB1 level at 13-23 weeks gestation was still an independent risk factor for GDM after 24 weeks of pregnancy (OR=1.573, 95%CI was 1.035 to 2.228, P<0.05). The area under the ROC curve of GDM was 0.631 (P<0.05). Conclusions Elevated serum SerpinB1 levels at 13-23 weeks of pregnancy is related to the risk of GDM occurrence after 24 weeks of pregnancy, which may be a serological marker before the occurrence of GDM. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Diabetes Mellitus is the property of Chinese Journal of Diabetes Mellitus and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To assess associations of bone turnover markers with metabolic syndrome (MS) among men in Henan Province. Methods From December 2015 to March 2016, a total of 697 male subjects were selected from the TIDE (Thyroid Disorders, lodine status and Diabetes: a National Epidemiological Survey‑2014) research‑‑Henan sub‑center survey using multistage stratified cluster random sampling. All included subjects received standard oral glucose tolerance test, a physical examination (height, weight, waist circumference and blood pressure), a collection of blood samples to determine the level of plasma glucose, glycated hemoglobin A1c, total cholesterol, triglyceride (TG), high‑density lipoprotein‑cholesterol, low‑density lipoprotein‑cholesterol, osteocalcin, pro‑collagen type 1 N‑terminal propeptide (PⅠNP), C‑terminal‑cross‑linking telopeptide of type 1 collagen (β‑CTX), 25‑hydroxyvitamin D [25(OH)D] and parathyroid hormone (PTH), and all of them completed the questionnaire. The associations between bone turnover markers and MS were analyzed using Spearman correlation and binary logistic regression, respectively. Results A total of 697 men with an age of (46.6±15.9) years were included in the study. The average body mass index (BMI) was (25.97±3.69) kg/m2 (17.1-39.0 kg/m2). After adjusted for age, PTH, 25(OH)D, BMI and smoke, BMI was found as a risk factor for MS (OR=1.263, 95%CI 1.198-1.332). Spearman correlation analysis showed that OC and PⅠNP was negatively associated with MS (r=-0.154, -0.107, both P＜0.01), but there was no significant correlation between β‑CTX and MS. The results of the binary logistic regression analysis showed that OC was a protective factor for MS, abdominal obesity, hyperglycemia, hypertension and high TG; after adjusted for age, PTH, 25(OH) D and BMI, osteocalcin was also a protective factor for hyperglycemia (OR=0.971, 95%CI 0.947-0.995) and high TG (OR=0.955, 95%CI 0.931-0.980); further adjusted for smoke, the results were same as before. PⅠNP was a protective factor for MS, abdominal obesity, hyperglycemia and hypertension; after adjusted for age, PTH and 25(OH)D, PⅠNP was also a protective factor for abdominal obesity (OR=0.993, 95%CI 0.988-0.999); further adjusted for BMI and smoke, there was no significant correlation between P Ⅰ NP and abdominal obesity. Conclusion Weight control is important to prevent adult males from MS, and higher levels of osteocalcin and PⅠNP may help prevent MS. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Diabetes Mellitus is the property of Chinese Journal of Diabetes Mellitus and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

唾液腺周围有丰富的毛细血管，可与血液进行分子交换，唾液中含有无机离子、葡萄糖、 1，5‑脱水葡萄糖醇等有机小分子，以及脂质、蛋白质及多种激素。测定唾液葡萄糖、1，5‑脱水葡萄糖 醇在糖尿病的筛查、监测中具有一定意义. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Diabetes Mellitus is the property of Chinese Journal of Diabetes Mellitus and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)