1. 血氧水平依赖磁共振成像评估2型糖尿病 患者早期肾缺氧改变.
- Author
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任俊杰, 李春霞, 徐东红, 苏卫东, 吴彩兰, 宋春青, 邱丽君, and 纪盛章
- Abstract
Objective To evaluate the value of blood oxygen level-dependent magnetic resonance imaging (BOLD-MRI) in the assessment of renal oxygenation of patients with type 2 diabetes mellitus (T2DM). Methods From April 2014 to October 2015, kidney scans were conducted in eighteen patients with T2DM and twenty-two healthy controls with a Philips 3.0T scanner by using a BOLD-MRI sequence. The medullary and cortical apparent relaxation rate(R2*)values were measured in both groups. Paired samples t-test and independent samples t-test were used in data comparison within or between groups. The correlation between the renal glomerular filtration rate estimated using cystatin C(CysC-GFR) and the R2* values was analyzed by Pearson correlation coefficient analysis. Results The medullary R2* values were significantly higher than those of cortex in both groups (t=21.5, 21.1,both P<0.01). The cortex R2* values in patients with T2DM and healthy controls were (15.3±1.9) and (15.0±1.7) 1/s respectively, and there was no significant differences between two groups (t=0.7, P>0.05). The medullary R2* values in the patients with T2DM and healthy controls were (38.1±4.1) and (29.6±2.7) 1/s respectively, it was significantly higher in the type 2 diabetic patients than that in healthy controls (t=8.0, P<0.01). Medullary R2* value had a high sensitivity (83.33%) and specificity (100%) in identifying patients with T2DM with an area under the receiver operating characteristic curve of 0.965, and the best testing threshold was 34.1 1/s. The medullary R2* value was found positively correlated with CysC-GFR level in patients with T2DM (r=0.7, P<0.01), but no correlation was found between the cortical R2* value and CysC-GFR (r=0.1, P>0.05). Conclusion BOLD-MRI can detect and assess the renal medullary hypoxia in patients with T2DM at the early stage, and medullary R2* value may reflect the changes of renal function. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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