1. Effects of neoadjuvant chemotherapy on MDR1 and MRP gene expression in primary breast cancer
- Author
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Xiao-dong Sun, Jin-Min Wu, and Xing-E Liu
- Subjects
Oncology ,Cancer Research ,medicine.medical_specialty ,Chemotherapy ,business.industry ,medicine.medical_treatment ,Drug resistance ,medicine.disease ,physiological processes ,Breast cancer ,stomatognathic system ,Internal medicine ,Medicine public health ,Gene expression ,polycyclic compounds ,Medicine ,In patient ,business ,Primary breast cancer ,neoplasms ,Gene - Abstract
Objective: To investigate the effects of neoadjuvant chemotherapy on the expression of drug resistance genes, multidrug resistance-1 (MDR1) and multidrug resistance-associated protein (MRP), in patients with primary breast cancer. Methods: MDR1 and MRP expression were detected by semi-quantitative RT-PCR in 20 patients with primary breast cancer, before and after chemotherapy. Results: Before chemotherapy, MDR1 and MRP expression can be detected in 15 cases (75%) and 18 cases (90%) respectively. After chemotherapy, expression of MDR1 is not significantly different from that before chemotherapy, but expression of MRP is significantly different from that before chemotherapy. Conclusion: Expression of drug resistance gene MRP, but not MDR1, is enhanced in patients with primary breast cancer submitted to neoadjuvant chemotherapy.
- Published
- 2004
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