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Background and objective In the recent years, uniportal video-assisted thoracic surgery (uniportal-VATS) is developing rapidly on the basis of traditional three portal VATS and has been applied for radical resection of lung cancer, its superiority on the clinical application compared with traditional VATS is also become the focus of the attention, the aim of this study is to preliminary investigate the effect of uniportal -VATS on post-operative pain and short-term quality of life. Methods Data of 216 patients who underwent uniportal-VATS (n=115) or three portal VATS (3P-VATS)(n=101) for radical resection of non-small cell lung cancer (NSCLC) were analyzed. The clinical and operative data were assessed, visual analogue scale (VAS) was used to evaluate the minimum and maximum pain score (VASmin and VASmax) on the 3rd and 7th post-operative day. Chinese version 4.0 of Functional Assessment of Cancer Treatment-Lung (FACT-L) was applied to evaluate the short-term quality of life preoperatively and 3 months after operation, respectively. Incidence of incision numbness and satisfaction rate of incision appearance were compared between the two groups 3 months after operation. Results Both groups were similar in clinical characteristics, there were no perioperative death in two groups. While the operative time of uniportal-VATS group (157.62±19.50) min was longer than that of the 3P-VATS group [(116.00±17.32) min, P

Background and objective Despite undergoing curative resection, the 5-year survival rate for stage III non-small cell lung cancer (NSCLC) patients is less than 25%. There is a need for biomarkers for prediction of survival and guiding individual therapy. MiR-155 is one of most commonly upregulated miRNAs in malignancies, and regulates multiple pro-oncogenic pathways. We aimed to investigate the prognostic impact of miR-155 in resected stage III NSCLC patients. Methods Tumor formalin-fixed, paraffin-embedded (FFPE) from 162 resected stage III NSCLC patients were collected. Total RNA including miRNA was extracted, and qRT-PCR was used to determine the expression of miR-155. Results Spearman rank correlation test showed a positive correlation between miR-155 expression and nodal status (r=0.169, P=0.032). MiR-155 expression had a significant prognostic impact in the total cohort (P