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Your search keyword '"Giuseppe Trigiante"' showing total 1 results
Start Over Author "Giuseppe Trigiante" Publisher chemical society of japan
1 results on '"Giuseppe Trigiante"'

1. 5-Iodo-4-thio-2'-deoxyuridine: Synthesis, Structure, and Cytotoxic Activity.

Author

Xiao-Hui Zhang, Hong-Yan Yin, Giuseppe Trigiante, Reto Brem, Peter Karran, Pitak, Mateusz B., Coles, Simon J., and Yao-Zhong Xu

Abstract

The novel nucleoside 5-iodo-4-thio-2'-deoxyuridine (4) was synthesized and fully characterized by IR, NMR, and MS. Its structure was determined by single-crystal X-ray diffraction. Compound 4 absorbs strongly at 346nm and is minimally toxic to human tumour cells, but its cytotoxicity is substantially enhanced by low dose UVA radiation. The combined use of 4 and UVA offers a promising route to selectively and effectively kill proliferating cells. [ABSTRACT FROM AUTHOR]

Published
2015
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