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6 results on '"Martin C.W. Chan"'

1. Use of Human Intestinal Enteroids to Detect Human Norovirus Infectivity

Author

Martin C.W. Chan, Jenny C M Chan, Kirran N. Mohammad, Mary K. Estes, Paul K.S. Chan, and Sarah K.C. Cheung

Subjects
Male, Microbiology (medical), China, enteroids, human norovirus, Epidemiology, viruses, rRT-PCR, 030231 tropical medicine, lcsh:Medicine, Biology, Real-Time Polymerase Chain Reaction, medicine.disease_cause, Sensitivity and Specificity, lcsh:Infectious and parasitic diseases, real-time reverse transcription PCR, Feces, 03 medical and health sciences, fluids and secretions, 0302 clinical medicine, Use of Human Intestinal Enteroids to Determine Human Norovirus Infectivity, medicine, Humans, lcsh:RC109-216, 030212 general & internal medicine, Aged, Caliciviridae Infections, Infectivity, Cycle threshold, infectivity, enteric infections, lcsh:R, Norovirus, Dispatch, Infant, virus diseases, Middle Aged, Virology, Ct cutoff, Reverse transcription polymerase chain reaction, Infectious Diseases, Hong Kong
Abstract

Tools to detect human norovirus infectivity have been lacking. Using human intestinal enteroid cultures inoculated with GII.Pe-GII.4 Sydney–infected fecal samples, we determined that a real-time reverse transcription PCR cycle threshold cutoff of 30 may indicate infectious norovirus. This finding could be used to help guide infection control.

Published
2019
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2. Global Trends in Norovirus Genotype Distribution among Children with Acute Gastroenteritis

Author

Leesa Bruggink, Christian Muñoz, Sidhartha Giri, Martin C.W. Chan, Joseph Bonifacio, Filemon Bucardo, Jan Vinjé, Rangaraj Selvarangan, Janet Mans, Chao-Yang Pan, Hannah Browne, Mustafiz Rahman, Xiao-Li Pang, Naomi Sakon, Joanne Hewitt, Leslie Barclay, Mark D. Gonzalez, Jennifer L. Cannon, Javier Buesa, Corinna Pietsch, Jih-Hui Lin, and Tulio M Fumian

Subjects
Adult, Microbiology (medical), NoroSurv, Surveillance data, Genotype, Epidemiology, viruses, 030231 tropical medicine, norovirus, Infectious and parasitic diseases, RC109-216, Biology, medicine.disease_cause, capsids, High strain, 03 medical and health sciences, dual typing, 0302 clinical medicine, fluids and secretions, children, genotypes, medicine, Humans, 030212 general & internal medicine, Typing, acute gastroenteritis, Child, Phylogeny, Caliciviridae Infections, Research, enteric infections, virus diseases, Acute gastroenteritis, vaccines, Virology, polymerase, food safety, Infectious Diseases, Liver, surveillance, Norovirus, Global Trends in Norovirus Genotype Distribution among Children with Acute Gastroenteritis, Medicine, P-types, gastroenteritis, Childhood age
Abstract

Noroviruses are a leading cause of acute gastroenteritis (AGE) among adults and children worldwide. NoroSurv is a global network for norovirus strain surveillance among children

Published
2021

3. Higher Viral Load of Emerging Norovirus GII.P16-GII.2 than Pandemic GII.4 and Epidemic GII.17, Hong Kong, China

Author

Martin C.W. Chan, Grace Lui, Lin-Yao Zhang, Paul K.S. Chan, Raymond Lai, E. Anthony S. Nelson, Kirsty Kwok, Ting Fan Leung, Kirran N. Mohammad, Sarah K.C. Cheung, and Nelson Lee

Subjects
Male, 0301 basic medicine, Epidemiology, viruses, lcsh:Medicine, Higher Viral Load of Emerging Norovirus GII.P16-GII.2 than Pandemic GII.4 and Epidemic GII.17, Hong Kong, China, medicine.disease_cause, Communicable Diseases, Emerging, fluids and secretions, Genotype, Pandemic, Child, Caliciviridae Infections, Norovirus GII, Dispatch, virus diseases, Middle Aged, Viral Load, Gastroenteritis, Infectious Diseases, Child, Preschool, Hong Kong, Female, Viral load, Adult, Microbiology (medical), China, Adolescent, norovirus, Biology, lcsh:Infectious and parasitic diseases, Young Adult, 03 medical and health sciences, Age groups, medicine, Humans, lcsh:RC109-216, epidemic GII.17, Pandemics, lcsh:R, Infant, emerging GII.P16-GII.2, Virology, pandemic GII.4, recombination, 030104 developmental biology, Norovirus
Abstract

We compared viral load of emerging recombinant norovirus GII.P16-GII.2 with those for pandemic GII.Pe-GII.4 and epidemic GII.P17-GII.17 genotypes among inpatients in Hong Kong. Viral load of GII.P16-GII.2 was higher than those for other genotypes in different age groups. GII.P16-GII.2 is as replication competent as the pandemic genotype, explaining its high transmissibility and widespread circulation.

Published
2018
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4. Increased Detection of Emergent Recombinant Norovirus GII.P16-GII.2 Strains in Young Adults, Hong Kong, China, 2016–2017

Author

Nelson Lee, Sonja Jacobsen, Kirsty Kwok, Paul K.S. Chan, Raymond Lai, Lok-Yi Chan, Martin C.W. Chan, Ting Fan Leung, Tin-Nok Hung, E. Anthony S. Nelson, and Sandra Niendorf

Subjects
Male, 0301 basic medicine, Epidemiology, viruses, lcsh:Medicine, medicine.disease_cause, Communicable Diseases, Emerging, Disease Outbreaks, recombinant norovirus, fluids and secretions, Increased Detection of Emergent Recombinant Norovirus GII.P16-GII.2 Strains in Young Adults, Hong Kong, China, Genotype, Pandemic, older children, GII, Young adult, Child, Phylogeny, Caliciviridae Infections, education.field_of_study, Dispatch, virus diseases, Middle Aged, Gastroenteritis, viral load, Infectious Diseases, Child, Preschool, Hong Kong, Female, Seasons, Viral load, Reassortant Viruses, Adult, young adults, Microbiology (medical), China, medicine.medical_specialty, Adolescent, 030106 microbiology, Population, Biology, lcsh:Infectious and parasitic diseases, Young Adult, 03 medical and health sciences, Molecular genetics, medicine, Humans, lcsh:RC109-216, education, Aged, lcsh:R, Norovirus, Infant, Virology, 030104 developmental biology
Abstract

A new recombinant norovirus GII.P16-GII.2 outnumbered pandemic GII.4 as the predominant GII genotype in the winter of 2016–2017 in Hong Kong, China. Half of hospitalized case-patients were older children and adults, including 13 young adults. This emergent norovirus targets a wider age population compared with circulating pandemic GII.4 strains.

Published
2017
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5. Bimodal Seasonality and Alternating Predominance of Norovirus GII.4 and Non-GII.4, Hong Kong, China, 2014–20171

Author

Grace Lui, Martin C.W. Chan, Ting Fan Leung, Raymond Lai, Nelson Lee, Paul K.S. Chan, Lin-Yao Zhang, E. Anthony S. Nelson, Kirsty Kwok, and Kirran N. Mohammad

Subjects
0301 basic medicine, Microbiology (medical), China, age distribution, bimodal seasonality, Epidemiology, viruses, Prevalence, norovirus, Biology, medicine.disease_cause, 03 medical and health sciences, fluids and secretions, 0302 clinical medicine, Vaccine strain, Bimodal Seasonality and Alternating Predominance of Norovirus GII.4 and Non-GII.4, Hong Kong, China, 2014–2017, Age groups, medicine, vaccine strain, 030212 general & internal medicine, Norovirus GII, Molecular epidemiology, geographic hotspot, Dispatch, virus diseases, Seasonality, medicine.disease, 030104 developmental biology, Infectious Diseases, surveillance, Norovirus, Hong Kong, non-GII.4, GII.4, Demography
Abstract

We report emerging subtropical bimodal seasonality and alternating predominance of norovirus GII.4 and non-GII.4 genotypes in Hong Kong. GII.4 predominated in summer and autumn months and affected young children, whereas emergent non-GII.4 genotypes predominated in winter months and affected all age groups. This highly dynamic epidemiology should inform vaccination strategies.

Published
2018
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6. Fecal Viral Concentration and Diarrhea in Norovirus Gastroenteritis

Author

Grace Lui, Wai K. Leung, Paul K.S. Chan, Martin C.W. Chan, Raymond Lai, Kin-Wing Choi, Bonnie C. K. Wong, Winnie W. Y. Sin, Joseph J.Y. Sung, Clive S. Cockram, and Nelson Lee

Subjects
Microbiology (medical), Adult, Diarrhea, Male, DNA, Complementary, Genotype, Epidemiology, viruses, lcsh:Medicine, medicine.disease_cause, Microbiology, lcsh:Infectious and parasitic diseases, Pathogenesis, Feces, fluids and secretions, viral concentration, medicine, Humans, lcsh:RC109-216, Dna viral, Aged, Caliciviridae Infections, Aged, 80 and over, business.industry, Transmission (medicine), lcsh:R, Norovirus, Dispatch, virus diseases, Middle Aged, Virology, digestive system diseases, Gastroenteritis, Infectious Diseases, DNA, Viral, Vomiting, Hong Kong, Female, medicine.symptom, business
Abstract

Fecal viral concentrations of 40 patients infected with norovirus genogroup GII.4 correlated with diarrhea duration and frequency of vomiting. Higher viral concentration and older age were independently associated with prolonged diarrhea (> or =4 days). These findings provide information on the pathogenesis and transmission of norovirus infections.

Published
2007
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