1. Durability of Antibody Response and Frequency of SARS-CoV-2 Infection 6 Months after COVID-19 Vaccination in Healthcare Workers
- Author
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Eric D. Laing, Carol D. Weiss, Emily C. Samuels, Si’Ana A. Coggins, Wei Wang, Richard Wang, Russell Vassell, Spencer L. Sterling, Marana S. Tso, Tonia Conner, Emilie Goguet, Matthew Moser, Belinda M. Jackson-Thompson, Luca Illinik, Julian Davies, Orlando Ortega, Edward Parmelee, Monique Hollis-Perry, Santina E. Maiolatesi, Gregory Wang, Kathleen F. Ramsey, Anatalio E. Reyes, Yolanda Alcorta, Mimi A. Wong, Alyssa R. Lindrose, Christopher A. Duplessis, David R. Tribble, Allison M.W. Malloy, Timothy H. Burgess, Simon D. Pollett, Cara H. Olsen, Christopher C. Broder, and Edward Mitre
- Subjects
Microbiology (medical) ,COVID-19 Vaccines ,Infectious Diseases ,SARS-CoV-2 ,Epidemiology ,Health Personnel ,Antibody Formation ,Vaccination ,COVID-19 ,Humans ,Antibodies, Viral - Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies decay but persist 6 months postvaccination; lower levels of neutralizing titers persist against Delta than wild-type virus. Of 227 vaccinated healthcare workers tested, only 2 experienced outpatient symptomatic breakthrough infections, despite 59/227 exhibiting serologic evidence of SARS-CoV-2 infection, defined as presence of nucleocapsid protein antibodies.
- Published
- 2022