11 results on '"Anne W. Rimoin"'
Search Results
2. Co-Circulating Monkeypox and Swinepox Viruses, Democratic Republic of the Congo, 2022
- Author
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Thierry Kalonji, Emile Malembi, Jean Paul Matela, Toutou Likafi, Eddy Kinganda-Lusamaki, Emmanuel Hasivirwe Vakaniaki, Nicole A. Hoff, Amuri Aziza, Francisca Muyembe, Joelle Kabamba, Tine Cooreman, Béatrice Nguete, Danae Witte, Ahidjo Ayouba, Nicolas Fernandez-Nuñez, Stijn Roge, Martine Peeters, Sydney Merritt, Steve Ahuka-Mundeke, Eric Delaporte, Elisabeth Pukuta, Joachim Mariën, Eugene Bangwen, Steven Lakin, Charles Lewis, Jeffrey B. Doty, Laurens Liesenborghs, Lisa E. Hensley, Andrea McCollum, Anne W. Rimoin, Jean Jacques Muyembe-Tamfum, Robert Shongo, Didine Kaba, and Placide Mbala-Kingebeni
- Subjects
monkeypox virus ,mpox ,swinepox virus ,swinepox ,orthopoxvirus ,infectious diseases ,Medicine ,Infectious and parasitic diseases ,RC109-216 - Abstract
In September 2022, deaths of pigs manifesting pox-like lesions caused by swinepox virus were reported in Tshuapa Province, Democratic Republic of the Congo. Two human mpox cases were found concurrently in the surrounding community. Specific diagnostics and robust sequencing are needed to characterize multiple poxviruses and prevent potential poxvirus transmission.
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- 2024
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3. Clade I–Associated Mpox Cases Associated with Sexual Contact, the Democratic Republic of the Congo
- Author
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Emile M. Kibungu, Emmanuel H. Vakaniaki, Eddy Kinganda-Lusamaki, Thierry Kalonji-Mukendi, Elisabeth Pukuta, Nicole A. Hoff, Isaac I. Bogoch, Muge Cevik, Gregg S. Gonsalves, Lisa E. Hensley, Nicola Low, Souradet Y. Shaw, Erin Schillberg, Mikayla Hunter, Lygie Lunyanga, Sylvie Linsuke, Joule Madinga, Martine Peeters, Jean-Claude Makangara Cigolo, Steve Ahuka-Mundeke, Jean-Jacques Muyembe, Anne W. Rimoin, Jason Kindrachuk, Placide Mbala-Kingebeni, and Robert S. Lushima
- Subjects
mpox ,monkeypox virus ,MPXV ,viruses ,sexually transmitted infections ,the Democratic Republic of the Congo ,Medicine ,Infectious and parasitic diseases ,RC109-216 - Abstract
We report a cluster of clade I monkeypox virus infections linked to sexual contact in the Democratic Republic of the Congo. Case investigations resulted in 5 reverse transcription PCR–confirmed infections; genome sequencing suggest they belonged to the same transmission chain. This finding demonstrates that mpox transmission through sexual contact extends beyond clade IIb.
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- 2024
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4. Use of High-Resolution Geospatial and Genomic Data to Characterize Recent Tuberculosis Transmission, Botswana
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Chelsea R. Baker, Ivan Barilar, Leonardo S. de Araujo, Anne W. Rimoin, Daniel M. Parker, Rosanna Boyd, James L. Tobias, Patrick K. Moonan, Eleanor S. Click, Alyssa Finlay, John E. Oeltmann, Vladimir N. Minin, Chawangwa Modongo, Nicola M. Zetola, Stefan Niemann, and Sanghyuk S. Shin
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tuberculosis and other mycobacteria ,bacteria ,respiratory infections ,whole-genome sequencing ,spatial analysis ,geographic heterogeneity ,Medicine ,Infectious and parasitic diseases ,RC109-216 - Abstract
Combining genomic and geospatial data can be useful for understanding Mycobacterium tuberculosis transmission in high-burden tuberculosis (TB) settings. We performed whole-genome sequencing on M. tuberculosis DNA extracted from sputum cultures from a population-based TB study conducted in Gaborone, Botswana, during 2012–2016. We determined spatial distribution of cases on the basis of shared genotypes among isolates. We considered clusters of isolates with ≤5 single-nucleotide polymorphisms identified by whole-genome sequencing to indicate recent transmission and clusters of ≥10 persons to be outbreaks. We obtained both molecular and geospatial data for 946/1,449 (65%) participants with culture-confirmed TB; 62 persons belonged to 5 outbreaks of 10–19 persons each. We detected geospatial clustering in just 2 of those 5 outbreaks, suggesting heterogeneous spatial patterns. Our findings indicate that targeted interventions applied in smaller geographic areas of high-burden TB identified using integrated genomic and geospatial data might help interrupt TB transmission during outbreaks.
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- 2023
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5. Serologic Prevalence of Ebola Virus in Equatorial Africa
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Imke Steffen, Kai Lu, Lauren K. Yamamoto, Nicole A. Hoff, Prime Mulembakani, Emile O. Wemakoy, Jean-Jacques Muyembe-Tamfum, Nicaise Ndembi, Catherine A. Brennan, John Hackett, Susan L. Stramer, William M. Switzer, Sentob Saragosti, Guy O. Mbensa, Syria Laperche, Anne W. Rimoin, and Graham Simmons
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Ebola virus ,viruses ,hemorrhagic fever virus ,folivirus ,serologic prevalence ,neutralization assay ,Medicine ,Infectious and parasitic diseases ,RC109-216 - Abstract
We conducted a serologic survey of 2,430 serum samples collected during 1997–2012 for various studies to determine the prevalence of the hemorrhagic fever virus Ebola virus (EBOV) in equatorial Africa. We screened serum samples for neutralizing antibodies by using a pseudotype microneutralization assay and a newly developed luciferase immunoprecipitation system assay. Specimens seroreactive for EBOV were confirmed by using an ELISA. Our results suggest a serologic prevalence of 2%–3.5% in the Republic of the Congo and the Democratic Republic of the Congo, which have reported outbreaks of infection with EBOV. In addition we detected a seroprevalence of 1.3% in southern Cameroon, which indicated a low risk for exposure in this region.
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- 2019
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- View/download PDF
6. Genomic Variability of Monkeypox Virus among Humans, Democratic Republic of the Congo
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Jeffrey R. Kugelman, Sara C. Johnston, Prime M. Mulembakani, Neville Kisalu, Michael S. Lee, Galina Koroleva, Sarah E. McCarthy, Marie C. Gestole, Nathan D. Wolfe, Joseph N. Fair, Bradley S. Schneider, Linda L. Wright, John Huggins, Chris A. Whitehouse, Emile Okitolonda Wemakoy, Jean Jacques Muyembe-Tamfum, Lisa E. Hensley, Gustavo F. Palacios, and Anne W. Rimoin
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Monkeypox virus ,genomic diversity ,emerging infectious disease ,genomic reduction ,gene loss ,Democratic Republic of the Congo ,Medicine ,Infectious and parasitic diseases ,RC109-216 - Abstract
Monkeypox virus is a zoonotic virus endemic to Central Africa. Although active disease surveillance has assessed monkeypox disease prevalence and geographic range, information about virus diversity is lacking. We therefore assessed genome diversity of viruses in 60 samples obtained from humans with primary and secondary cases of infection from 2005 through 2007. We detected 4 distinct lineages and a deletion that resulted in gene loss in 10 (16.7%) samples and that seemed to correlate with human-to-human transmission (p = 0.0544). The data suggest a high frequency of spillover events from the pool of viruses in nonhuman animals, active selection through genomic destabilization and gene loss, and increased disease transmissibility and severity. The potential for accelerated adaptation to humans should be monitored through improved surveillance. Download MP3 Length: 1:11
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- 2014
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7. Exposure to Wild Primates among HIV-infected Persons
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Matthew LeBreton, Otto Yang, Ubald Tamoufe, Eitel Mpoudi-Ngole, Judith N. Torimiro, Cyrille F. Djoko, Jean K. Carr, A. Tassy Prosser, Anne W. Rimoin, Deborah L. Birx, Donald S. Burke, and Nathan D. Wolfe
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Africa ,Central ,acquired immunodeficiency syndrome ,HIV-1 ,immunocompromised host ,zoonoses ,Medicine ,Infectious and parasitic diseases ,RC109-216 - Abstract
HIV-1 is an immunosuppressive pathogen. Our behavioral data for 191 HIV-1–infected rural Cameroonians show frequent exposure to nonhuman primates through activities such as hunting and butchering. Immunosuppression among persons exposed to body fluids of wild nonhuman primates could favor the process of adaptation and subsequent emergence of zoonotic pathogens.
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- 2007
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8. Epidemiology of Human Parvovirus 4 Infection in Sub-Saharan Africa
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Colin P. Sharp, Marion Vermeulen, Yacouba K. Nébié, Cyrille F. Djoko, Matthew LeBreton, Ubald Tamoufe, Anne W. Rimoin, Patrick K. Kayembe, Jean K. Carr, Annabelle Servant-Delmas, Syria Laperche, G.L. Abby Harrison, Oliver G. Pybus, Eric Delwart, Nathan D. Wolfe, Andrew Saville, Jean-Jacques Lefrère, and Peter Simmonds
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Viruses ,human parvovirus ,PARV4 ,parenteral transmission ,HIV/AIDS and other retroviruses ,hepatitis C virus ,Medicine ,Infectious and parasitic diseases ,RC109-216 - Abstract
Human parvovirus 4 infections are primarily associated with parenteral exposure in western countries. By ELISA, we demonstrate frequent seropositivity for antibody to parvovirus 4 viral protein 2 among adult populations throughout sub-Saharan Africa (Burkina Faso, 37%; Cameroon, 25%; Democratic Republic of the Congo, 35%; South Africa, 20%), which implies existence of alternative transmission routes.
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- 2010
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9. Endemic Human Monkeypox, Democratic Republic of Congo, 2001–2004
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Anne W. Rimoin, Neville Kisalu, Benoit Kebela-Ilunga, Thibaut Mukaba, Linda L. Wright, Pierre Formenty, Nathan D. Wolfe, Robert Loshima Shongo, Florimond Tshioko, Emile Okitolonda, Jean-Jacques Muyembe, Robert W. Ryder, and Hermann Meyer
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Human monkeypox ,monkeypox virus ,chickenpox ,varicella-zoster virus ,VZV ,Democratic Republic of Congo ,Medicine ,Infectious and parasitic diseases ,RC109-216 - Abstract
By analyzing vesicle fluids and crusted scabs from 136 persons with suspected monkeypox, we identified 51 cases of monkeypox by PCR, sequenced the hemagglutinin gene, and confirmed 94% of cases by virus culture. PCR demonstrated chickenpox in 61 patients. Coinfection with both viruses was found in 1 additional patient.
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- 2007
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10. Serologic Prevalence of Ebola Virus in Equatorial Africa
- Author
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Catherine A. Brennan, Susan L. Stramer, Lauren K. Yamamoto, Jean-Jacques Muyembe-Tamfum, Sentob Saragosti, Nicaise Ndembi, William M. Switzer, Nicole A. Hoff, Syria Laperche, Guy Olivier Mbensa, Imke Steffen, Prime Mulembakani, John Hackett, Graham Simmons, Kai Lu, Anne W. Rimoin, and Emile Okitolonda Wemakoy
- Subjects
Blood transfusion ,Epidemiology ,medicine.medical_treatment ,lcsh:Medicine ,medicine.disease_cause ,Antibodies, Viral ,Ghana ,Serology ,Ebola virus ,0302 clinical medicine ,Viral Envelope Proteins ,Seroepidemiologic Studies ,neutralization assay ,Medicine ,Uganda ,Viral ,Cameroon ,030212 general & internal medicine ,Central ,biology ,Viral Core Proteins ,hemorrhagic fever virus ,Hemorrhagic fever virus ,Ebolavirus ,3. Good health ,pseudotypes ,Infectious Diseases ,Medical Microbiology ,Ebola ,Democratic Republic of the Congo ,Public Health and Health Services ,ELISA ,Antibody ,Infection ,filovirus ,Microbiology (medical) ,Republic of the Congo ,Clinical Sciences ,030231 tropical medicine ,Enzyme-Linked Immunosorbent Assay ,Microbiology ,serologic prevalence ,Antibodies ,lcsh:Infectious and parasitic diseases ,Vaccine Related ,03 medical and health sciences ,Biodefense ,folivirus ,Microneutralization Assay ,Seroprevalence ,Humans ,Immunoprecipitation ,Africa, Central ,viruses ,lcsh:RC109-216 ,business.industry ,Prevention ,Research ,lcsh:R ,Outbreak ,equatorial Africa ,Hemorrhagic Fever, Ebola ,Virology ,Emerging Infectious Diseases ,Good Health and Well Being ,HEK293 Cells ,Nucleoproteins ,Africa ,biology.protein ,Hemorrhagic Fever ,business ,luciferase immunoprecipitation system - Abstract
We conducted a serologic survey of 2,430 serum samples collected during 1997-2012 for various studies to determine the prevalence of the hemorrhagic fever virus Ebola virus (EBOV) in equatorial Africa. We screened serum samples for neutralizing antibodies by using a pseudotype microneutralization assay and a newly developed luciferase immunoprecipitation system assay. Specimens seroreactive for EBOV were confirmed by using an ELISA. Our results suggest a serologic prevalence of 2%-3.5% in the Republic of the Congo and the Democratic Republic of the Congo, which have reported outbreaks of infection with EBOV. In addition we detected a seroprevalence of 1.3% in southern Cameroon, which indicated a low risk for exposure in this region.
- Published
- 2019
11. Exposure to Wild Primates among HIV-infected Persons
- Author
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Nathan D. Wolfe, Eitel Mpoudi-Ngole, Deborah L. Birx, Cyrille F. Djoko, Jean K. Carr, Judith N. Torimiro, Ubald Tamoufe, A. Tassy Prosser, Anne W. Rimoin, Otto O. Yang, Matthew LeBreton, and Donald S. Burke
- Subjects
Male ,Rural Population ,Epidemiology ,medicine.medical_treatment ,lcsh:Medicine ,HIV Infections ,Disease susceptibility ,Hiv infected ,Zoonoses ,Surveys and Questionnaires ,Cameroon ,Pathogen ,Central ,0303 health sciences ,Dispatch ,Immunosuppression ,Middle Aged ,3. Good health ,Infectious Diseases ,Behavioral data ,Medical Microbiology ,Public Health and Health Services ,Female ,Occupational exposure ,Disease Susceptibility ,Rural population ,Abattoirs ,Microbiology (medical) ,Adult ,Primates ,Adolescent ,Clinical Sciences ,Wild ,Animals, Wild ,Biology ,Microbiology ,lcsh:Infectious and parasitic diseases ,03 medical and health sciences ,Immunocompromised Host ,Occupational Exposure ,medicine ,Animals ,Humans ,lcsh:RC109-216 ,Occupations ,030304 developmental biology ,immunocompromised host ,030306 microbiology ,lcsh:R ,acquired immunodeficiency syndrome ,Virology ,zoonoses ,Immunology ,Africa ,HIV-1 - Abstract
HIV-1 is an immunosuppressive pathogen. Our behavioral data for 191 HIV-1-infected rural Cameroonians show frequent exposure to nonhuman primates through activities such as hunting and butchering. Immunosuppression among persons exposed to body fluids of wild nonhuman primates could favor the process of adaptation and subsequent emergence of zoonotic pathogens.
- Published
- 2007
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