1. Statin Use and Influenza Vaccine Effectiveness in Persons >65 Years of Age, Taiwan.
- Author
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Lung-Wen Tsai, Yung-Tai Chen, Chia-Jen Shih, Shuo-Ming Ou, Pei-Wen Chao, Shih-Hsiu Lo, Tsai, Lung-Wen, Chen, Yung-Tai, Shih, Chia-Jen, Ou, Shuo-Ming, Chao, Pei-Wen, and Lo, Shih-Hsiu
- Subjects
VACCINE effectiveness ,INFLUENZA vaccines ,CRITICALLY ill ,INFLUENZA - Abstract
Debates on whether statin use reduces the effectiveness of influenza vaccines against critical illness and death among persons >65 years of age continue. We conducted a study of 9,427,392 persons >65 years of age who did and did not receive influenza vaccinations during 12 consecutive influenza seasons, 2000-01 through 2011-12. Using data from Taiwan's National Health Insurance Research Database, we performed propensity score-matching to compare vaccinated persons with unvaccinated controls. After propensity score-matching, the vaccinated group had lower risks for in-hospital death from influenza and pneumonia and for hospitalization for pneumonia and influenza, circulatory conditions, and critical illnesses compared with the unvaccinated group. We stratified the 2 groups by statin use and analyzed data by interaction analysis and saw no statistically significant difference. We found that influenza vaccine effectively reduced risks for hospitalization and death in persons >65 years of age, regardless of statin use. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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