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Objective: To define epidemiological and nosological structure of patients with chronic heart failure (CHF) according to hospitals of tertiary level of the Kyrgyz Republic (National Center of Cardiology and Therapy and Scientific Research Institute of Heart Surgery and Organs Transplantation). Methods: Overall, 25415 patients medical records, patients of all ages provided treatment in the period of 2017 - 2018 in hospitals of tertiary level of the city of Bishkek were studied and analyzed. We also retrospectively studied cases with CHF referred to SRIHSOT outpatients department from city of Bishkek, observed from 2005 to 2018. In total, we included 3420 outpatient cards in the analysis. Results: According to National Center of Cardiology and Therapy, patients with NYHA FC I-II - 57.18% (14533) prevail and in this category, female persons - 57.60% prevail. The basic etiological reason of development of CHF in adult patients with FC – I-II is coronary heart disease in 33.00% of cases. Arterial hypertension, which occurred in 5624 patients (24.43%), was the most frequent accompanying pathology. According to Scientific Research Institute of Heart Surgery and Organs Transplantation among the referred patients with CHF the females (1930, 56.4%) prevail and patients with CHF and preserved ejection fraction (50% and more) (2706, 79.1%) prevail. Conclusion: Thus, in patients with CHF referred to NCCT, patients with FC I-II prevail and in this category female sex prevail. The main etiological reason of development of CHF in adult patients with FC – I-II is coronary artery disease followed by arterial hypertension. Among patients with CHF referred to SRIHSOT, female sex and CHF with preserved ejection fraction prevail. The 1st stage of CHF is registered in the majority of patients. Overall 72.4% of patients referred to SRIHSOT with CHF underwent surgery.

Objective: The data on the relationship between the level of TNF-α and interleukin-10 with the presence of left ventricular hypertrophy and myocardial remodeling in patients with essential hypertension is presented. Methods: Overall, 156 patients with essential hypertension aged 40 to 75 years (with mean age 55.8 ± 7.5 years) were examined; of which 57 were women and 99 were men. All patients were divided into two groups. The first group included 73 patients showing the presence of left ventricular hypertrophy (LVH), established by echocardiography; the second group included 83 patients who showed no signs of LVH on the echocardiogram. Results: According to the study, no relationship was found between the concentration of tumor necrosis factor α (TNF-α) and the development of LVH. It was also shown that only men, but not women with, were associated with the presence of LVH with low levels of interleukin-10 ( IL-10). In addition, a negative correlation was found between the concentration of tumor necrosis factor α (TNF-α) and IL-10 with the thickness of the left ventricular walls at the initial stages of myocardial remodeling on the echocardiography. Conclusion: Thus, our study demonstrates the modulating role of inflammation on the processes of myocardial remodeling in hypertension.