1. Role of a Probiotic Strain in the Modulation of Gut Microbiota and Cytokines in Inflammatory Bowel Disease
- Author
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V Deepak Bamola, Divya Dubey, Projoyita Samanta, Saurabh Kedia, Vineet Ahuja, Ratna Sudha Madempudi, Jayanthi Neelamraju, and Rama Chaudhry
- Subjects
Infectious Diseases ,Tumor Necrosis Factor-alpha ,Probiotics ,Humans ,Cytokines ,Bifidobacterium ,Inflammatory Bowel Diseases ,Microbiology ,Gastrointestinal Microbiome - Abstract
Human gut is one of the major niches for anaerobes which play diverse functional role in host physiology and development. Gut microbiota maintains a homeostasis and dysbiosis may contribute in pathogenesis of different diseases including inflammatory bowel disease (IBD). Probiotic intervention is an established approach to maintain microbial homeostasis for the prevention and treatment of different diseases. The efficacy of probiotic strain Bacillus clausii UBBC-07 has been demonstrated and established in various diseases but its efficacy in IBD is under reported. To assess the effect of Bacillus clausii UBBC-07 in IBD patients, a randomized controlled study was conducted. Patients were randomly allocated to either placebo or probiotic B clausii UBBC-07 for four weeks along with the standard medical treatment (SMT). Enrolled patients were evaluated before and after intervention for GI survival of the given probiotic, change in GI microbiota, change in serum cytokines, serotonin and dopamine, symptoms of disease, physical, behavioral and psychological parameters. B clausii UBBC-07 showed good survival in IBD patients in the treatment group (p
- Published
- 2022
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