1. Apoptosis: a link between cancer genetics and chemotherapy.
- Author
-
Johnstone RW, Ruefli AA, and Lowe SW
- Subjects
- Animals, Antineoplastic Agents pharmacology, Drug Resistance, Neoplasm, Humans, Models, Biological, Neoplasms pathology, Neoplasms physiopathology, Signal Transduction physiology, Antineoplastic Agents therapeutic use, Apoptosis drug effects, Neoplasms drug therapy, Neoplasms genetics
- Abstract
Defects in apoptosis underpin both tumorigenesis and drug resistance, and because of these defects chemotherapy often fails. Understanding the molecular events that contribute to drug-induced apoptosis, and how tumors evade apoptotic death, provides a paradigm to explain the relationship between cancer genetics and treatment sensitivity and should enable a more rational approach to anticancer drug design and therapy.
- Published
- 2002
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