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1. Of Mice Not Men? Actions of Interleukin-6 on Glucose Tolerance.

Author

McGlone ER and Tan TM

Subjects
Animals, Blood Glucose, Gastric Emptying, Humans, Insulin, Male, Mice, Peptide Fragments, Glucagon, Interleukin-6
Abstract

In mice, interleukin-6 (IL-6) improves glucose tolerance via stimulation of glucagon-like peptide 1 (GLP-1) secretion. In this issue of Cell Metabolism, Lang Lehrskov et al. (2018) demonstrate that IL-6 infusion has GLP-1-dependent and -independent actions with opposing effects on glucose tolerance, resulting in an overall improvement in healthy male volunteers but no improvement in male patients with diabetes., (Copyright © 2018 Elsevier Inc. All rights reserved.)

Published
2018
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