1. The CD26-Related Dipeptidyl Aminopeptidase-like Protein DPPX Is a Critical Component of Neuronal A-Type K+ Channels
- Author
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Nadal, Marcela S., Ozaita, Andrés, Amarillo, Yimy, de Miera, Eleazar Vega-Saenz, Ma, Yuliang, Mo, Wenjun, Goldberg, Ethan M., Misumi, Yoshio, Ikehara, Yukio, Neubert, Thomas A., and Rudy, Bernardo
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PEPTIDASE , *POTASSIUM channels - Abstract
Subthreshold-activating somatodendritic A-type potassium channels have fundamental roles in neuronal signaling and plasticity which depend on their unique cellular localization, voltage dependence, and kinetic properties. Some of the components of A-type K+ channels have been identified; however, these do not reproduce the properties of the native channels, indicating that key molecular factors have yet to be unveiled. We purified A-type K+ channel complexes from rat brain membranes and found that DPPX, a protein of unknown function that is structurally related to the dipeptidyl aminopeptidase and cell adhesion protein CD26, is a novel component of A-type K+ channels. DPPX associates with the channels'' pore-forming subunits, facilitates their trafficking and membrane targeting, reconstitutes the properties of the native channels in heterologous expression systems, and is coexpressed with the pore-forming subunits in the somatodendritic compartment of CNS neurons. [Copyright &y& Elsevier]
- Published
- 2003
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