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1. Keep Them Close: PRC2 Poises Enhancer-Promoter Interactions at Anterior Neuronal Genes.

Author

Caglio G, Torlai Triglia E, and Pombo A

Subjects
Animals, Epigenesis, Genetic genetics, Humans, Mice, Models, Theoretical, Polycomb Repressive Complex 2 genetics, Enhancer Elements, Genetic genetics, Neurons metabolism, Polycomb Repressive Complex 2 metabolism, Promoter Regions, Genetic genetics
Abstract

Enhancers exist in different epigenetic states: active, primed, or poised. However, it is not yet understood how the different enhancer states influence gene activation. In this issue of Cell Stem Cell, Cruz-Molina et al. (2017) unravel how poised enhancers activate anterior neural genes and the role of Polycomb proteins in enhancer-promoter contacts., (Copyright © 2017 Elsevier Inc. All rights reserved.)

Published
2017
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