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Your search keyword '"Bone Marrow Cells parasitology"' showing total 2 results
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2 results on '"Bone Marrow Cells parasitology"'

1. Bone-Marrow-Resident NK Cells Prime Monocytes for Regulatory Function during Infection.

Author

Askenase MH, Han SJ, Byrd AL, Morais da Fonseca D, Bouladoux N, Wilhelm C, Konkel JE, Hand TW, Lacerda-Queiroz N, Su XZ, Trinchieri G, Grainger JR, and Belkaid Y

Subjects
Animals, Antigens, Ly metabolism, Basic-Leucine Zipper Transcription Factors genetics, Basic-Leucine Zipper Transcription Factors metabolism, Bone Marrow Cells parasitology, Cell Differentiation, Cells, Cultured, Interferon-gamma metabolism, Interleukin-12 genetics, Interleukin-12 metabolism, Intestinal Mucosa parasitology, Killer Cells, Natural parasitology, Leukocytes, Mononuclear parasitology, Lymphocyte Activation, Mice, Mice, Inbred C57BL, Mice, Knockout, Models, Immunological, Organ Specificity immunology, Repressor Proteins genetics, Repressor Proteins metabolism, Bone Marrow Cells immunology, Dendritic Cells immunology, Intestinal Mucosa immunology, Killer Cells, Natural immunology, Leukocytes, Mononuclear immunology, Toxoplasma immunology, Toxoplasmosis immunology
Abstract

Tissue-infiltrating Ly6C(hi) monocytes play diverse roles in immunity, ranging from pathogen killing to immune regulation. How and where this diversity of function is imposed remains poorly understood. Here we show that during acute gastrointestinal infection, priming of monocytes for regulatory function preceded systemic inflammation and was initiated prior to bone marrow egress. Notably, natural killer (NK) cell-derived IFN-γ promoted a regulatory program in monocyte progenitors during development. Early bone marrow NK cell activation was controlled by systemic interleukin-12 (IL-12) produced by Batf3-dependent dendritic cells (DCs) in the mucosal-associated lymphoid tissue (MALT). This work challenges the paradigm that monocyte function is dominantly imposed by local signals after tissue recruitment, and instead proposes a sequential model of differentiation in which monocytes are pre-emptively educated during development in the bone marrow to promote their tissue-specific function., (Copyright © 2015 Elsevier Inc. All rights reserved.)

Published
2015
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2. Control of T helper 2 responses by transcription factor IRF4-dependent dendritic cells.

Author

Gao Y, Nish SA, Jiang R, Hou L, Licona-Limón P, Weinstein JS, Zhao H, and Medzhitov R

Subjects
Allergens immunology, Animals, Bone Marrow Cells cytology, Bone Marrow Cells immunology, Bone Marrow Cells parasitology, Cell Differentiation, Coculture Techniques, Dendritic Cells parasitology, Dendritic Cells pathology, Gene Expression Regulation, Interferon Regulatory Factors genetics, Mice, Mice, Transgenic, Nippostrongylus immunology, Ovalbumin immunology, Signal Transduction, Strongylida Infections parasitology, Strongylida Infections pathology, T-Lymphocytes, Regulatory immunology, T-Lymphocytes, Regulatory parasitology, T-Lymphocytes, Regulatory pathology, Th1 Cells immunology, Th1 Cells parasitology, Th1 Cells pathology, Th2 Cells parasitology, Th2 Cells pathology, Dendritic Cells immunology, Immunity, Cellular, Interferon Regulatory Factors immunology, Strongylida Infections immunology, Th2 Cells immunology
Abstract

CD4⁺ T cell differentiation is regulated by specialized antigen-presenting cells. Dendritic cells (DCs) produce cytokines that promote naive CD4⁺ T cell differentiation into T helper 1 (Th1), Th17, and inducible T regulatory (iTreg) cells. However, the initiation of Th2 cell responses remains poorly understood, although it is likely that more than one mechanism might be involved. Here we have defined a specific DC subset that is involved in Th2 cell differentiation in vivo in response to a protease allergen, as well as infection with Nippostrongylus brasiliensis. We have demonstrated that this subset is controlled by the transcription factor interferon regulatory factor 4 (IRF4), which is required for their differentiation and Th2 cell-inducing function. IRF4 is known to control Th2 cell differentiation and Th2 cell-associated suppressing function in Treg cells. Our finding suggests that IRF4 also plays a role in DCs where it controls the initiation of Th2 cell responses., (Copyright © 2013 Elsevier Inc. All rights reserved.)

Published
2013
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