1. A Functional Polymorphism in COL11A1, Which Encodes the α1 Chain of Type XI Collagen, Is Associated with Susceptibility to Lumbar Disc Herniation.
- Author
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Mio, Futoshi, Chiba, Kazuhiro, Hirose, Yuichiro, Kawaguchi, Yoshiharu, Mikami, Yasuo, Oya, Takeshi, Mori, Masaki, Kamata, Michihiro, Matsumoto, Morio, Ozaki, Kouichi, Tanaka, Toshihiro, Takahashi, Atsushi, Kubo, Toshikazu, Kimura, Tomoatsu, Toyama, Yoshiaki, and Ikegawa, Shiro
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HERNIA , *SOCIAL degeneration , *INTERVERTEBRAL disk , *COLLAGEN , *GENES - Abstract
Lumbar disc herniation (LDH), degeneration and herniation of the nucleus pulposus of the intervertebral disc (IVD) of the lumbar spine, is one of the most common musculoskeletal diseases. Its etiology and pathogenesis, however, remain unclear. Type XI collagen is important for cartilage collagen formation and for organization of the extracellular matrix. We identified an association between one of the type XI collagen genes, COL11A1, and LDH in Japanese populations. COL11A1, which encodes the a1 chain of type XI collagen, was highly expressed in IVD, but its expression was decreased in the IVD of patients with LDH. The expression level was inversely correlated with the severity of disc degeneration. A single-nucleotide polymorphism (c.4603C→T [rs1676486]) had the most significant association with LDH (P = 3.3 x 10-6), and the transcript containing the disease-associated allele was decreased because of its decreased stability. These observations indicate that type XI collagen is critical for IVD metabolism and that its decrease is related to LDH. [ABSTRACT FROM AUTHOR]
- Published
- 2007
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