1. Mucormycotic infection in mice following prolonged incubation of spores in vivo and the role of spore agglutinating antibodies on spore germination.
- Author
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Waldorf AR, Peter L, and Polak A
- Subjects
- Agglutinins analysis, Animals, Antibodies, Fungal analysis, Immunity drug effects, Lung Diseases, Fungal microbiology, Male, Mice, Mice, Inbred Strains, Mucorales drug effects, Mucorales physiology, Mucormycosis microbiology, Spores, Fungal immunology, Spores, Fungal physiology, Antibodies, Fungal physiology, Lung Diseases, Fungal immunology, Mucorales immunology, Mucormycosis immunology
- Abstract
Following intranasal inoculation of mice, Rhizomucor pusillus spores are gradually cleared from the lung, with the clearance complete at 30 days. Incubation of R. pusillus spores in vivo for up to 14 days after intranasal inoculation resulted in pulmonary mucormycosis when the mice were then treated with cortisone. Spore-agglutinating IgM antibodies were detected in normal adult mice and R. pusillus-inoculated but not cortisone-treated mice. There was no correlation between antispore antibody titers and spore germination in vitro. The absence of germinated R. pusillus in inoculated but non-cortisone-treated mice appears to be due to a reversible inhibition of spore germination rather than destruction of spores by the host. The factor(s) that restrict spore germination are reversible and do not appear to be spore agglutinating antibodies.
- Published
- 1984
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