1. Therapeutic implications of cancer stem cells in prostate cancer.
- Author
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Banerjee, Pinaki, Kapse, Prachi, Siddique, Shehnaz, Kundu, Moumita, Choudhari, Jasoda, Mohanty, Varshasnata, Malhotra, Diksha, Gosavi, Suresh W., Gacche, Rajesh N., and Kundu, Gopal C.
- Subjects
CANCER stem cells ,PROSTATE cancer ,CELL populations ,CELL communication ,DISEASE progression ,DRUG resistance - Abstract
Prostate cancer, one of the most frequently occurring cancers in men, is a heterogeneous disease involving multiple cell types within tumors. This tumor heterogeneity at least partly results from genomic instability leading to sub-clonal cellular differentiation. The differentiated cell populations originate from a small subset of cells with tumor-initiating and stem-like properties. These cells, termed prostate cancer stem cells (PCSCs), play crucial roles in disease progression, drug resistance, and relapse. This review discusses the origin, hierarchy, and plasticity of PCSCs; methods for isolation and enrichment of PCSCs; and various cellular and metabolic signaling pathways involved in PCSC induction and maintenance, as well as therapeutic targeting. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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