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Concentrations of dioctyl sodium sulfosuccinate (DSS) ranging from three to five times the recommended dosage produced severe diarrhea, rapid dehydration and death in seven horses and 66 guinea pigs when administered experimentally per os. Clinicopathological findings indicated hemoconcentration in both horses and guinea pigs. There was a leucocytosis in the guinea pigs given the highest dosages. In all cases the principal finding at necropsy was extreme fluid distention of the intestinal tract. There was histopathological evidence of epithelial denudation and vascular stasis. The LD50 in the guinea pig was approximately 0.65 g DSS/kg body weight.

Wasting disease was observed in hamsters inoculated at birth with a cell-free bovine leukemic extract. The autopsy and histological examination of the runted hamsters revealed visible lesions in the lymphoid tissues. These lesions consisted mostly in depletion of lympocytes in the spleen and in the cortex of the lymph nodes and in atrophy of the Peper's patches. Thymic lesions were also observed. Anemia and a decrease of circulating lymphocytes were observed in the peripheral blood.