1. One week of overeating upregulates angiogenic and lipolytic gene expression in human subcutaneous adipose tissue from exercise trained and untrained adults
- Author
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Alison C. Ludzki, Emily M. Krueger, Jenna B. Gillen, Natalie M. Taylor, Darby O. Middlebrook, Toree C. Baldwin, Konstantinos C. Karabetsos, Michael W. Schleh, and Jeffrey F. Horowitz
- Subjects
Adult ,Nutrition and Dietetics ,Physiology ,Endocrinology, Diabetes and Metabolism ,Subcutaneous Fat ,Gene Expression ,General Medicine ,Hyperphagia ,Subcutaneous Fat, Abdominal ,Article ,PPAR gamma ,Isophane Insulin, Human ,Adipose Tissue ,Physiology (medical) ,Humans ,Insulin Resistance - Abstract
Effective storage of excess energy in abdominal subcutaneous adipose tissue during periods of overeating may help attenuate weight-gain-related insulin resistance. The objective of this study was to assess changes in the expression of factors regulating abdominal subcutaneous adipose tissue storage capacity in response to a brief exposure to overeating in nonobese adults. Because exercise can alter the expression of genes involved in regulating adipose tissue storage capacity, we compared the responses to overeating in regular exercisers (EX, n = 11) and nonexercisers (nonEX, n = 11). Abdominal subcutaneous adipose tissue samples and oral glucose tolerance tests were performed before and after participants ate 30% above their estimated daily energy requirements for 1 week. Both EX and nonEX gained ∼1 kg ( P
- Published
- 2022