1. No allelic association between harm avoidance and the debrisoquine 4-hydroxylase gene
- Author
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Theo J M Ingenhoven, Adriaan H Veefkind, and Izaäk W De Groot
- Subjects
Genetics ,medicine.medical_specialty ,CYP2D6 ,media_common.quotation_subject ,medicine.disease ,Psychiatry and Mental health ,chemistry.chemical_compound ,Debrisoquine ,chemistry ,medicine ,Harm avoidance ,Personality ,Temperament and Character Inventory ,Temperament ,Big Five personality traits ,Allele ,Psychiatry ,Psychology ,Biological Psychiatry ,media_common - Abstract
Background:Several reports suggest that variance in personality traits is inherited, but little is known about the genes responsible. It has been suggested that there is a relationship between personality characteristics and the gene responsible for the activity of the enzyme debrisoquine 4-hydroxylase (CYP2D6).Objective:To examine the proportion of poor metabolizers in a group of personality disordered patients.Methods:Blood samples were obtained from 23 patients with a high or very high score on the dimension ‘harm avoidance’ of the Temperament and Character Inventory (TCI). The samples were genotyped for the null alleles CYP2D6*3 and*4 by performing an allele-specific polymerase chain reaction.Results:The frequencies of genotypes in the sample were very similar to the frequencies found in a general white population.Conclusions:The investigation produced no support for the idea that the CYP2D6 gene is related to personality by means of variations in the temperament dimension of harm avoidance.
- Published
- 2002