1. EPA guidance on the early detection of clinical high risk states of psychoses
- Author
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Schultze-Lutter, F., Michel, C., Schmidt, S. J., Schimmelmann, B. G., Maric, N. P., Salokangas, R. K. R., Riecher-Rössler, A., van der Gaag, M., Nordentoft, M., Raballo, A., Meneghelli, A., Marshall, M., Morrison, A., Ruhrmann, S., and Klosterkötter, J.
- Subjects
Prevention of psychosis in Europe ,Adult ,Male ,Children and adolescents ,Adolescent ,Risk Assessment ,Young Adult ,03 medical and health sciences ,Transient psychotic symptoms (BLIPS) ,0302 clinical medicine ,Cognitive disturbances (COGDIS) ,Risk Factors ,Early Medical Intervention ,Humans ,Child ,Psychiatric Status Rating Scales ,Mood Disorders ,Attenuated psychotic symptoms (APS) ,Meta-analysis ,Antipsychotic Agents ,Cognition Disorders ,Female ,Practice Guidelines as Topic ,Psychotic Disorders ,Schizophrenia ,Treatment Outcome ,Early Diagnosis ,Psychiatry and Mental Health ,ta3124 ,030227 psychiatry ,Psychiatry and Mental health ,sense organs ,030217 neurology & neurosurgery - Abstract
The aim of this guidance paper of the European Psychiatric Association is to provide evidence-based recommendations on the early detection of a clinical high risk (CHR) for psychosis in patients with mental problems. To this aim, we conducted a meta-analysis of studies reporting on conversion rates to psychosis in non-overlapping samples meeting any at least any one of the main CHR criteria: ultra-high risk (UHR) and/or basic symptoms criteria. Further, effects of potential moderators (different UHR criteria definitions, single UHR criteria and age) on conversion rates were examined. Conversion rates in the identified 42 samples with altogether more than 4000 CHR patients who had mainly been identified by UHR criteria and/or the basic symptom criterion ‘cognitive disturbances’ (COGDIS) showed considerable heterogeneity. While UHR criteria and COGDIS were related to similar conversion rates until 2-year follow-up, conversion rates of COGDIS were significantly higher thereafter. Differences in onset and frequency requirements of symptomatic UHR criteria or in their different consideration of functional decline, substance use and co-morbidity did not seem to impact on conversion rates. The ‘genetic risk and functional decline’ UHR criterion was rarely met and only showed an insignificant pooled sample effect. However, age significantly affected UHR conversion rates with lower rates in children and adolescents. Although more research into potential sources of heterogeneity in conversion rates is needed to facilitate improvement of CHR criteria, six evidence-based recommendations for an early detection of psychosis were developed as a basis for the EPA guidance on early intervention in CHR states.
- Published
- 2015