1. Comparing the epidemiology of hospital-acquired methicillin-resistant Staphylococcus aureus clone groups in Alberta, Canada
- Author
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Elizabeth Henderson, David Vickers, A. Rusk, S. Bruzzese, Marie Louie, Vincent Li, Joseph Kim, Kathryn Bush, Jenine Leal, Sumana Fathima, and Linda Chui
- Subjects
Male ,Methicillin-Resistant Staphylococcus aureus ,0301 basic medicine ,medicine.medical_specialty ,Epidemiology ,030106 microbiology ,Population ,030501 epidemiology ,medicine.disease_cause ,Staphylococcal infections ,Alberta ,03 medical and health sciences ,Risk Factors ,Acute care ,Internal medicine ,Drug Resistance, Bacterial ,medicine ,Humans ,Infection control ,Intensive care medicine ,education ,Aged ,Aged, 80 and over ,Cross Infection ,education.field_of_study ,Molecular epidemiology ,business.industry ,Middle Aged ,Staphylococcal Infections ,biochemical phenomena, metabolism, and nutrition ,bacterial infections and mycoses ,medicine.disease ,Original Papers ,Methicillin-resistant Staphylococcus aureus ,Anti-Bacterial Agents ,Infectious Diseases ,Socioeconomic Factors ,Staphylococcus aureus ,Female ,0305 other medical science ,business - Abstract
SUMMARYPatients with methicillin-resistant Staphylococcus aureus (MRSA) clones, which were traditionally seen in the community setting (USA400/CMRSA7 and USA300/CMRSA10), are often identified as hospital-acquired (HA) infections using Infection Prevention and Control (IPC) surveillance definitions. This study examined the demographics and healthcare risk factors of patients with HA-MRSA to help understand if community MRSA clones are from a source internal or external to the hospital setting. Despite USA300/CMRSA10 being the predominant clone in Alberta, hospital clones (USA100/CMRSA2) still dominated in the acute care setting. In the Alberta hospitalized population, patients with USA400/CMRSA7 and USA300/CMRSA10 clones were significantly younger, had fewer comorbidities, and a greater proportion had none or ambulatory care-only healthcare exposure. These findings suggest that there are two distinct populations of HA-MRSA patients, and the patients with USA400/CMRSA7 and USA300/CMRSA10 clones identified in hospital more greatly resemble patients affected by those clones in the community. It is possible that epidemiological assessment overidentifies HA acquisition of MRSA in patients unscreened for MRSA on admission to acute care.
- Published
- 2016
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