1. X-ray diffraction data of tibolone Δ4 isomer (isotibolone)
- Author
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Gabriel Lima Barros de Araujo, Fabio Furlan Ferreira, Carlos O. Paiva-Santos, Jivaldo do Rosário Matos, and Selma Gutierrez Antonio
- Subjects
Diffraction ,Radiation ,Materials science ,Infrared spectroscopy ,Synchrotron radiation ,Tibolone ,Condensed Matter Physics ,Synchrotron ,law.invention ,Crystallography ,law ,Elemental analysis ,X-ray crystallography ,medicine ,General Materials Science ,Thermal analysis ,Instrumentation ,medicine.drug - Abstract
Tibolone is used for hormone reposition of postmenopause women and isotibolone is considered the major degradation product of tibolone. Isotibolone can also be present in tibolone API raw materials due to some inadequate synthesis. Its presence is then necessary to be identified and quantified in the quality control of both API and drug products. In this work we present the indexing of an isotibolone X-ray diffraction pattern measured with synchrotron light (λ=1.2407 Å) in the transmission mode. The characterization of the isotibolone sample by IR spectroscopy, elemental analysis, and thermal analysis are also presented. The isotibolone crystallographic data are a=6.8066 Å, b=20.7350 Å, c=6.4489 Å, β=76.428°, V=884.75 Å3, and space group P21, ρo=1.187 g cm−3, Z=2.
- Published
- 2009
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