1. Role of Chlamydia trachomatis and emerging Chlamydia-related bacteria in ectopic pregnancy in Vietnam.
- Author
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Hornung S, Thuong BC, Gyger J, Kebbi-Beghdadi C, Vasilevsky S, Greub G, and Baud D
- Subjects
- Abortion, Spontaneous blood, Adult, Case-Control Studies, Chlamydia Infections blood, Chlamydia Infections epidemiology, Chlamydia trachomatis isolation & purification, Chlamydiales immunology, Chlamydiales isolation & purification, DNA, Bacterial analysis, Fallopian Tubes chemistry, Fallopian Tubes microbiology, Female, Humans, Immunoglobulin G blood, Placenta chemistry, Placenta microbiology, Pregnancy, Pregnancy Complications, Infectious epidemiology, Pregnancy Complications, Infectious microbiology, Pregnancy, Ectopic blood, Pregnancy, Ectopic epidemiology, Seroepidemiologic Studies, Vietnam epidemiology, Young Adult, Antibodies, Bacterial blood, Chlamydia Infections microbiology, Chlamydia trachomatis immunology, Pregnancy, Ectopic microbiology
- Abstract
In this case-control study, we investigated the seroprevalence and molecular evidence of Chlamydia trachomatis and Waddlia chondrophila in ectopic pregnancies (EP) and uneventful control pregnancies in 343 women from Vietnam. Whereas presence of C. trachomatis IgG was strongly associated with EP [adjusted odds ratio (aOR) 5·41, 95% confidence interval (CI) 2·58-11·32], its DNA remained undetected in all tubal lesions. We confirmed an independent association between antibodies against Waddlia and previous miscarriage (aOR 1·87, 95% CI 1·02-3·42). Further investigations are needed to understand the clinical significance of Waddlia's high seroprevalence (25·9% in control pregnancies) in this urban population.
- Published
- 2015
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