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Psychotic illness is managed and treated with best results when it is recognized at the earliest stages of a person developing the disorder, or when that person is identified as being at high risk of doing so. Describing a stage-specific model highlighting the risk, the clinical and biological factors present during the development of the illness, and the best treatments available for each of these stages, this new edition will guide practitioners and researchers in the adoption of carefully planned management strategies fully integrating treatment with prevention. Issues such as resistance to drugs and vocational recovery are covered, with related topics such as service organization and community education. This will be essential reading for all those involved in the care of people with early psychotic illness, or those responsible for the organization of services.

As a comprehensive reference on all aspects of the histiocytic disorders, Histiocytic Disorders of Children and Adults stands out a seminal text on the genetics, pathophysiology and clinical management of this wide range of diseases. The chapters, written by acknowledged experts in the field, cover all aspects of hystiocytic disorders, from Langerhans cell histiocytosis and hemophagocytic lymphohistiocytosis, to the uncommon cutaneous and extracutaneous histiocytic disorders. Views on the function of normal histiocytes in the immune system, the pathogenesis, underlying genetic defects, clinical presentation, treatment, controversies in therapy, salvage therapies and the late consequences are discussed in detail. Originally published in 2005, this book will be a valuable resource to clinicians and researchers who wish to learn more about histiocytic disorders.

Treatment for drug misuse has been dominated in recent years by the use of methadone as a substitution agent in heroin dependency. This approach has had considerable success, but as a result other treatment options have been neglected. This book draws on the author's direct clinical experience and makes use of international research findings to provide a comprehensive and detailed guide to service provision and treatment for drug misuse, including methadone and alternative opiate substitutes, detoxification methods, naltrexone and relapse prevention, and possible approaches with non-opiate users. There is a particular emphasis on social factors in drug misuse and dependency, and the consequent treatment issues and practical difficulties, and case studies are used throughout. Combining a highly practical approach with a strong research base, this book will be an essential resource for psychiatrists and other professionals involved in the management of drug misuse.

The treatment of early psychosis has been bedevilled by an entrenched pessimism, stemming from the asylum era and the Kraepelinian model of schizophrenia. More recently, however, there has been a surge of interest in preventively oriented treatment of patients showing the first signs of psychotic illness, with the realization that these illnesses are frequently highly responsive to early treatment. This is the first text to focus on the potential of early detection of psychosis, and the practicalities of treatment. Based on the pioneering experience and research of a now well-established prevention and intervention centre, and with contributions from international authorities, the book outlines a framework for intervention, reviews the evidence available to guide clinical practice, and describes models of treatment. Incorporating many personal narratives and case histories, it is strong on theory, sensitive on practical issues, and will challenge, inform and guide clinicians.