1. AGPAT3 Gene polymorphisms are associated with milk production traits in Chinese Holstein cows.
- Author
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Sun, Xiaomei, Liang, Yan, Gao, Qisong, Guo, Jiahe, Tang, Cheng, Shi, Kerong, Yang, Zhangping, and Mao, Yongjiang
- Subjects
MILK yield ,GENETIC polymorphisms ,SINGLE nucleotide polymorphisms ,COWS ,BINDING sites ,GENETIC correlations ,CATTLE genetics - Abstract
The current study reports the identification of previously undiscovered single-nucleotide polymorphisms (SNPs) in the bovine AGPAT3 gene and further investigates their associations with milk production traits. Our results demonstrate that the major allele C of the SNP g.12264 C > T is positively correlated with test-day milk yield, protein percentage and 305-day milk yield. Importantly, in silico analysis showed that the C/T transition at this locus gives rise to two new transcription factor binding sites (TFBS), E2F1 and Nkx3-2. Polymorphism g.18658 G > A was the only SNP associated with milk urea nitrogen (MUN) with the G allele related to an increase in milk urea nitrogen as well as fat percentage. The GG genotype of SNP g.28731 A > G was associated with the highest fat and protein percentage and lowest 305-day milk yield and somatic cell score (SCS). The association between AGPAT3 locus and milk production traits could be utilized in marker-assisted selection for the genetic improvement of milk production traits and, probably in conjunction with other traits, for selection to improve fitness of dairy cattle. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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