Search

Your search keyword '"MCCRINDLE, BRIAN W."' showing total 33 results
Start Over Author "MCCRINDLE, BRIAN W." Publisher cambridge university press
33 results on '"MCCRINDLE, BRIAN W."'

1. Impaired coronary microvascular reactivity in youth with bipolar disorder.

Author

Kennedy, Kody G., Ghugre, Nilesh R., Roifman, Idan, Qi, Xiuling, Saul, Kayla, McCrindle, Brian W., Macgowan, Christopher K., MacIntosh, Bradley J., and Goldstein, Benjamin I.

Subjects
BIPOLAR disorder, CORONARY disease, CORONARY circulation
Abstract

Background: Cardiovascular disease (CVD) is excessively prevalent and premature in bipolar disorder (BD), even after controlling for traditional cardiovascular risk factors. The increased risk of CVD in BD may be subserved by microvascular dysfunction. We examined coronary microvascular function in relation to youth BD. Methods: Participants were 86 youth, ages 13–20 years (n = 39 BD, n = 47 controls). Coronary microvascular reactivity (CMVR) was assessed using quantitative T 2 magnetic resonance imaging during a validated breathing-paradigm. Quantitative T2 maps were acquired at baseline, following 60-s of hyperventilation, and every 10-s thereafter during a 40-s breath-hold. Left ventricular structure and function were evaluated based on 12–15 short- and long-axis cardiac-gated cine images. A linear mixed-effects model that controlled for age, sex, and body mass index assessed for between-group differences in CMVR (time-by-group interaction). Results: The breathing-paradigm induced a significant time-related increase in T 2 relaxation time for all participants (i.e. CMVR; β = 0.36, p < 0.001). CMVR was significantly lower in BD v. controls (β = −0.11, p = 0.002). Post-hoc analyses found lower T 2 relaxation time in BD youth after 20-, 30-, and 40 s of breath-holding (d = 0.48, d = 0.72, d = 0.91, respectively; all p FDR < 0.01). Gross left ventricular structure and function (e.g. mass, ejection fraction) were within normal ranges and did not differ between groups. Conclusion: Youth with BD showed evidence of subclinically impaired coronary microvascular function, despite normal gross cardiac structure and function. These results converge with prior findings in adults with major depressive disorder and post-traumatic stress disorder. Future studies integrating larger samples, prospective follow-up, and blood-based biomarkers are warranted. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

3. Prevalence and associated factors of posttraumatic stress disorder in parents whose infants have single ventricle heart disease.

Author

Bainton, Jessica, Trachtenberg, Felicia, McCrindle, Brian W., Ke Wang, Boruta, Richard, Brosig, Cheryl L., Egerson, D’Andrea, Sood, Erica, Calderon, Johanna, Doman, Tammy, Golub, Katrina, Graham, Amanda, Haas, Karen, Hamstra, Michelle, Lindauer, Bergen, Sylvester, Donna, Woodard, Frances, Young-Borkowski, Lisa, and Mussatto, Kathleen A.

Published
2023
Full Text
View/download PDF

4. Registry-based trials: a potential model for cost savings?

Author

Anderson, Brett R., Gotlieb, Evelyn G., Hill, Kevin, McHugh, Kimberly E., Scheurer, Mark A., Mery, Carlos M., Pelletier, Glenn J., Kaltman, Jonathan R., White, Owen J., Trachtenberg, Felicia L., Hollenbeck-Pringle, Danielle, McCrindle, Brian W., Sylvester, Donna M., Eckhauser, Aaron W., Pasquali, Sara K., Anderson, Jeffery B., Schamberger, Marcus S., Shashidharan, Subhadra, Jacobs, Jeffrey P., and Jacobs, Marshall L.

Published
2020
Full Text
View/download PDF

8. Translating clinical trials into clinical practice: a survey assessing the potential impact of the Pediatric Heart Network Infant Single Ventricle Trial.

Author

Zak, Victor, Chen, Shan, McCrindle, Brian W., Frommelt, Michele A., Altmann, Karen, Hsu, Daphne T., Pemberton, Victoria L., Levine, Jami C., Atz, Andrew M., Cnota, James F., Ravishankar, Chitra, Barker, Piers, Lambert, Linda M., Williams, Richard V., and Pediatric Heart Network Investigators

Published
2017
Full Text
View/download PDF

9. Foetal echocardiographic assessment of borderline small left ventricles can predict the need for postnatal intervention

Author

Weber, Roland W, Ayala-Arnez, Ricardo, Atiyah, Merna, Etoom, Yousef, Manlhiot, Cedric, McCrindle, Brian W, Hickey, Edward J, Jaeggi, Edgar T, Nield, Lynne E, Weber, Roland W, Ayala-Arnez, Ricardo, Atiyah, Merna, Etoom, Yousef, Manlhiot, Cedric, McCrindle, Brian W, Hickey, Edward J, Jaeggi, Edgar T, and Nield, Lynne E

Abstract

Background We sought to prospectively determine foetal echocardiographic factors associated with neonatal interventions in borderline hypoplastic left ventricles. Methods Foetuses were included who had a left ventricle that was 2-4 standard deviations below normal for length or diameter and had forward flow across the mitral and aortic valves. Factors associated with an intervention in the first month of life or no need for intervention were sought using univariate and multivariate logistic regression models. Results From 2005 to 2008, 47 foetuses meeting the criteria had an additional diagnosis (+foetal coarctation/+transverse arch hypoplasia): atrioventricular septal defect 7 (+2/+0), double outlet right ventricle 2 (+0/+0), Shone's complex 19 (+9/+4), and ventricular disproportion 19 (+13/+11; 4 both). There were seven pregnancies terminated, three foetal demises, and five had compassionate care. There were 32 livebirths that either had a biventricular repair (n = 20, n = 2 dead), univentricular palliation (n = 2, both alive), or no intervention (n = 9). Overall survival of livebirths to 6 months of age was 79%. Factors associated with early intervention on first foetal echocardiogram were: obstructed or retrograde arch flow (p = 0.08, odds ratio 3.3), coarctation (p = 0.05, odds ratio 11.4), and left ventricle outflow obstruction (p = 0.05, odds ratio 12.5). Neonatal factors included: Shone's diagnosis (p = 0.02, odds ratio 4.9), bicuspid aortic valve (p = 0.005, odds ratio 11.7), and larger tricuspid valve z-score (p = 0.05, odds ratio 3.6). A neonatal factor associated with no intervention was a larger mitral valve z-score (mean −3.8 versus −4.2 intervention group, p = 0.04, odds ratio 2.8). Discussion The need for early intervention in foetuses with borderline hypoplastic left ventricle can be predicted by foetal echocardiography

Published
2013

15. Parental factors associated with screen time in pre-school children in primary-care practice: a TARGet Kids! study.

Author

Birken, Catherine S, Maguire, Jonathon, Mekky, Magda, Manlhiot, Cedric, Beck, Carolyn E, Jacobson, Sheila, Peer, Michael, Taylor, Carolyn, McCrindle, Brian W, Parkin, Patricia C, and TARGet Kids! collaboration

Abstract

Objective: To identify child and parental factors associated with screen time in 3-year-old children.Design: Observational study.Setting: Participants were recruited from a large primary-care paediatric group practice in Toronto, Canada.Subjects: Healthy 3-year-old children were included. A questionnaire was completed by their parents on screen time. Descriptive statistics and linear regression models were used to assess associations between child screen time and selected factors. Multivariable models included factors from the univariate analysis with P < 0·1. Estimated effects and 95% CI are reported.Results: A total of 157 children were enrolled (91% recruitment). The mean screen time per weekday was 104 min (similar for weekend day). In all, 10% of children had a television (TV) in their bedroom; 59% consumed at least one meal while watching TV; and 81% of parents had household rules about screen time. Controlling for maternal education and age, eating lunch and dinner in front of the screen and mother being employed were associated with an increase in child weekday screen time of 96 (95% CI 30, 192), 42 (95% CI 12, 90) and 36 (95% CI 6, 72) min/d, respectively. Eating lunch in front of the screen and an increase of 1 h of parental screen time were associated with an increase of 78 (95% CI 36, 132) and 12 (95% CI 6, 18) min/d in child weekend screen time. Family rules decreased child weekend screen time by 30 (95% CI 6, 54) min/d.Conclusions: Interventions that include these important parental factors should be evaluated for their effectiveness in reducing screen time. [ABSTRACT FROM AUTHOR]

Published
2011
Full Text
View/download PDF

32. Prevalence and associated factors of post-traumatic stress disorder in parents whose infants have single ventricle heart disease.

Author

Bainton J, Trachtenberg F, McCrindle BW, Wang K, Boruta R, Brosig CL, Egerson D, Sood E, Calderon J, Doman T, Golub K, Graham A, Haas K, Hamstra M, Lindauer B, Sylvester D, Woodard F, Young-Borkowski L, and Mussatto KA

Subjects
Child, Female, Infant, Humans, Prevalence, Cohort Studies, Parents psychology, Stress, Psychological psychology, Stress Disorders, Post-Traumatic epidemiology, Stress Disorders, Post-Traumatic etiology, Heart Diseases complications
Abstract

Introduction: Post-traumatic stress disorder occurs in parents of infants with CHD, contributing to psychological distress with detrimental effects on family functioning and well-being. We sought to determine the prevalence and factors associated with post-traumatic stress disorder symptoms in parents whose infants underwent staged palliation for single ventricle heart disease., Materials and Methods: A large longitudinal multi-centre cohort study evaluated 215 mothers and fathers for symptoms of post-traumatic stress disorder at three timepoints, including post-Norwood, post-Stage II, and a final study timepoint when the child reached approximately 16 months of age, using the self-report questionnaire Impact of Event Scale - Revised., Results: The prevalence of probable post-traumatic stress disorder post-Norwood surgery was 50% of mothers and 39% of fathers, decreasing to 27% of mothers and 24% of fathers by final follow-up. Intrusive symptoms such as flashbacks and nightmares and hyperarousal symptoms such as poor concentration, irritability, and sudden physical symptoms of racing heart and difficulty breathing were particularly elevated in parents. Higher levels of anxiety, reduced coping, and decreased satisfaction with parenting were significantly associated with symptoms of post-traumatic stress disorder in parents. Demographic and clinical variables such as parent education, pre-natal diagnosis, medical complications, and length of hospital stay(s) were not significantly associated with symptoms of post-traumatic stress disorder., Discussion: Parents whose infants underwent staged palliation for single ventricle heart disease often reported symptoms of post-traumatic stress disorder. Symptoms persisted over time and routine screening might help identify parents at-risk and prompt referral to appropriate supports.

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results