1. Neuroleptic associated tardive dyskinesias in young people with psychoses.
- Author
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Pourcher, Emmanuelle, Baruch, Philippe, Hugo Bouchard, Roch, Filteau, Marie-Josée, Bergeron, Danielle, Pourcher, E, Baruch, P, Bouchard, R H, Filteau, M J, and Bergeron, D
- Subjects
TARDIVE dyskinesia ,PSYCHOSES ,ANTIPSYCHOTIC agents ,DYSTONIA ,PEOPLE with mental illness ,PHARMACODYNAMICS - Abstract
Background: Apart from ageing, the factors associated with vulnerability to the emergence of tardive dyskinesia are poorly defined.Method: Risk factors associated with the presence of a chronic choreic or dystonic disorder were assessed in a cross-sectional comparison of anamnestic and clinical data in a homogeneous group of 64 young psychotic patients (under 40 years of age) on chronic low to moderate doses of neuroleptics.Results: Dyskinetic subjects presented more indirect indicators of occult brain damage, such as a perinatal event or traumatic brain injuries in infancy and early childhood; neurological examination showed more anomalies in dyskinetic patients than in nondyskinetics, with a higher prevalence of facial release reflexes.Conclusion: These data may support the hypothesis that occult acquired brain damage is important in the genesis of this 'drug-induced' disorder. [ABSTRACT FROM AUTHOR]- Published
- 1995
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