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Start Over Descriptor "Aminobutyrates cerebrospinal fluid" Publisher cambridge university press

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1. Gamma-aminobutyric acid (GABA) in the CSF of schizophrenic patients before and after neuroleptic treatment.

Author

Lichtshtein D, Dobkin J, Ebstein RP, Biederman J, Rimon R, and Belmaker RH

Subjects
Adult, Female, Humans, Male, Middle Aged, Schizophrenia drug therapy, Aminobutyrates cerebrospinal fluid, Schizophrenia cerebrospinal fluid, Tranquilizing Agents therapeutic use, gamma-Aminobutyric Acid cerebrospinal fluid
Abstract

Gamma-aminobutyric acid (GABA) levels in the CSF were measured in 9 normal individuals, 17 drug-free schizophrenic patients and 10 of these same schizophrenic patients after neuroleptic treatment. There was no significant difference between CSF level of GABA in the control group compared to those in schizophrenic patients; however, 6 of the 7 lowest GABA levels were from schizophrenic patients. There was a significant decline of 12 per cent in mean GABA levels in the CSF after a mean of two months of neuroleptic treatment.

Published
1978
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