1. Fronto-parietal white matter microstructural deficits are linked to performance IQ in a first-episode schizophrenia Han Chinese sample.
- Author
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Wang, Q., Cheung, C., Deng, W., Li, M., Huang, C., Ma, X., Wang, Y., Jiang, L., McAlonan, G., Sham, P., Collier, D. A., Gong, Q., Chua, S. E., and Li, T.
- Subjects
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BRAIN , *RADIOGRAPHY , *HYPOTHESIS , *ANALYSIS of variance , *CHI-squared test , *COMPARATIVE studies , *STATISTICAL correlation , *FRONTAL lobe , *INTELLECT , *INTELLIGENCE tests , *HANDEDNESS , *MAGNETIC resonance imaging , *CLASSIFICATION of mental disorders , *REGRESSION analysis , *RESEARCH funding , *SCHIZOPHRENIA , *T-test (Statistics) , *DICOM (Computer network protocol) , *DATA analysis software , *DESCRIPTIVE statistics - Abstract
BackgroundEvidence shows that cognitive deficits and white matter (WM) dysconnectivity can independently be associated with clinical manifestations in schizophrenia. It is important to explore this triadic relationship in order to investigate whether the triplet could serve as potential extended endophenotypes of schizophrenia.MethodDiffusion tensor images and clinical performances were evaluated in 122 individuals with first-episode schizophrenia and 122 age- and gender-matched controls. In addition, 65 of 122 of the patient group and 40 of 122 controls were measured using intelligence quotient (IQ) testing.ResultsThe schizophrenia group showed lower fractional anisotropy (FA) values than controls in the right cerebral frontal lobar sub-gyral (RFSG) WM. The schizophrenia group also showed a significant positive correlation between FA in the RFSG and performance IQ (PIQ); in turn, their PIQ score showed a significant negative correlation with negative syndromes.ConclusionsOverall, these findings support the hypothesis that WM deficits may be a core deficit that contributes to cognitive deficits as well as to negative symptoms. [ABSTRACT FROM PUBLISHER]
- Published
- 2013
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