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Archaeological studies of temporal changes in human predation strategy using foraging theory tend to focus on the role of overexploitation of important prey resources and resulting resource depression. An alternative use of the prey- choice model framed under foraging theory is to investigate the influence of environmental changes, such as increases in climate stress, on prey availability. Environmental change can be expected to produce many of the same effects on human predation strategy as resource depression. Here analytical techniques typically used to study the effects of over-predation and resource depression caused by humans are used to monitor their response to fluctuations in prey availability related to climate change during the Holocene in Missouri. Data and interpretations presented here add to the growing body of zooarchaeological foraging theory literature implicating environmental change as a critical factor in human diet. [ABSTRACT FROM AUTHOR]