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In a context of rapid technological innovation and expensive new products, the paper calls for the generation of real-world data to inform decision-making and an international discussion on the affordability of new medicines, particularly for low- and middle-income countries. Without these, the challenges of health judicialization will continue to grow. [ABSTRACT FROM AUTHOR]

The COVID-19 pandemic of 2020 was one of the rare events that shocked almost every world government simultaneously, thus creating an unusual opportunity to understand how political institutions shape policy decisions. There have been many analyses of what governments did. We focus instead on what they could do, focusing on the institutional politics of agency – how institutions empower rather than how they constrain, and how they affect public policy decisions. We examine public health measures in the first wave (March-September 2020) in Brazil, India, and the U.S. to understand how the interplay of institutions in a complex federal context shaped COVID-19 policy-responses. We find similar patterns of concentrated federal executive agency with limited constraints. In each case, when federal leadership failed public health policy responses, federated, subnational states were left to compensate for these inefficiencies without necessary resources. [ABSTRACT FROM AUTHOR]

This paper provides evidence on monetary policy transmission for five key emerging market economies: Brazil, Russia, India, China, and South Africa. Monetary policy (interest rate) shocks are identified using modern Bayesian methods along with the more recent sign restrictions approach. We find that contractionary monetary policy has a strong and negative effect on output. We also show that such contractionary monetary policy shocks do tend to stabilize inflation in these countries in the short term, while producing a strongly persistent negative effect on real equity prices. Overall, the impulse responses are robust to the alternative identification procedures. [ABSTRACT FROM AUTHOR]

Shocks related to weather variations have strong effects on developing countries' economies. Climate change is expected to increase the occurrence and magnitude of extreme weather events such as droughts, floods or hurricanes that strongly affect agriculture and other activities. This special issue gathers literature reviews and case studies that aim to better understand heterogeneous impacts and their transmission channels, as well as to evaluate the impact of such weather shocks on developing economies, including Sub-Saharan African countries, India and Brazil. [ABSTRACT FROM AUTHOR]

BackgroundIn this global study we sought to estimate the degree to which a family member might feel embarrassed when a close relative is suffering from an alcohol, drug, or mental health condition (ADMC) versus a general medical condition (GMC). To date, most studies have considered embarrassment and stigma in society and internalized by the afflicted individual but have not assessed family embarrassment in a large-scale study.MethodIn 16 sites of the World Mental Health Surveys (WMHS), standardized assessments were completed including items on family embarrassment. Site matching was used to constrain local socially shared determinants of stigma-related feelings, enabling a conditional logistic regression model that estimates the embarrassment close relatives may hold in relation to family members affected by an ADMC, a GMC, or both conditions.ResultsThere was a statistically robust association such that subgroups with an ADMC-affected relative were more likely to feel embarrassed compared to subgroups with a relative affected by a GMC (p < 0.001), even with covariate adjustments for age and sex.ConclusionsThe pattern of evidence from this research is consistent with conceptual models for interventions that target individual- and family-level stigma-related feelings of embarrassment as possible obstacles to effective early intervention and treatment for an ADMC. Macro-level interventions are under way but micro-level interventions may also be required among family members, along with care for each person with an ADMC. [ABSTRACT FROM PUBLISHER]

The results of research on the water relations and irrigation needs of coconut are collated and summarized in an attempt to link fundamental studies on crop physiology to drought mitigation and irrigation practices. Background information on the centres of origin and production of coconut and on crop development processes is followed by reviews of plant water relations, crop water use and water productivity, including drought mitigation. The majority of the recent research published in the international literature has been conducted in Brazil, Kerala (South India) and Sri Lanka, and by CIRAD (France) in association with local research organizations in a number of countries, including the Ivory Coast. The unique vegetative structure of the palm (stem and leaves) together with the long interval between flower initiation and the harvesting of the mature fruit (44 months) mean that causal links between environmental factors (especially water) are difficult to establish. The stomata play an important role in controlling water loss, whilst the leaf water potential is a sensitive indicator of plant water status. Both stomatal conductance and leaf water potential are negatively correlated with the saturation deficit of the air. Although roots extend to depths >2 m and laterally >3 m, the density of roots is greatest in the top 0–1.0 m soil, and laterally within 1.0–1.5 m of the trunk. In general, dwarf cultivars are more susceptible to drought than tall ones. Methods of screening for drought tolerance based on physiological traits have been proposed. The best estimates of the actual water use (ETc) of mature palms indicate representative rates of about 3 mm d−1. Reported values for the crop coefficient (Kc) are variable but suggest that 0.7 is a reasonable estimate. Although the sensitivity of coconut to drought is well recognized, there is a limited amount of reliable data on actual yield responses to irrigation although annual yield increases (50%) of 20–40 nuts palm−1 (4–12 kg copra, cultivar dependent) have been reported. These are only realized in the third and subsequent years after the introduction of irrigation applied at a rate equivalent to about 2 mm d−1 (or 100 l palm−1 d−1) at intervals of up to one week. Irrigation increases female flower production and reduces premature nut fall. Basin irrigation, micro-sprinklers and drip irrigation are all suitable methods of applying water. Recommended methods of drought mitigation include the burial of husks in trenches adjacent to the plant, mulching and the application of common salt (chloride ions). An international approach to addressing the need for more information on water productivity is recommended. [ABSTRACT FROM PUBLISHER]