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Iontophoresis is one of the most widely studied active techniques for enhancing transdermal delivery of drugs. However, its ability to enhance the delivery of highly lipophilic compounds is poor due to lack of any charge and poor water solubility of molecules. The skin has been used as a port for systemic delivery of therapeutic agents since several decades. The composition of stratum corneum renders it a daunting barrier to the topical and transdermal administration of therapeutic agents. The number of drug molecules for transdermal delivery is limited owing to the physicochemical restrictions. The delivery of drugs into systemic circulation via skin has generated much attention during the last decade. Transdermal therapeutic systems propound controlled release of active ingredients through the skin and into the systemic circulation in a predictive manner. Drugs administered through these systems escape first-pass metabolism and maintain a steady state scenario similar to a continuous intravenous infusion for up to several days. Keywords: Iontophoresis, non-invasive, stratum corneum, acid-alkaline reaction, chemical permeation enhancer, reverse iontophoresis.

Most of the infectious diseases due to pathogens are caused by the mucosal tract penetration. Hence, vaccines delivered directly to the mucosal tissues can defend pathogenic infections and provide protection at the first site of infection. Thus, mucosal, specifically, oral delivery is becoming the most ideal mode of vaccination. However, oral vaccines have to overcome numerous barriers such as the extremely low pH of the stomach, the presence of proteolytic enzymes and bile salts as well as low permeability in the intestine. Several formulations based on nanoparticles like liposomes, solid solutions, emulsions, VLPs are currently being used to prepare stable oral vaccine formulations. In current days different companies are trying to develop oral vaccine for COVID 19 also. This review briefly discusses several vaccine development criteria their mechanisms and various aspects of oral nanoparticles-based vaccine design that should be considered for improved mucosal and systemic immune responses. Keywords: Vaccine development, nanoparticles, liposome, VLP, COVID 19, mucosal immunity.

The main goal of the pharmacoeconomics is to addresses whether an additional gain from a medical intervention is worth paying extra cost based on three aspects of health outcomes: Economic, Clinical and Humanistic outcome known as ECHO Model. Bys perceptive the principles, methods, and application of pharmacoeconomics, pharmacists will be prepared to make better, more-informed decisions regarding the use of pharmaceutical products and services, that is, decisions that ultimately represent the best interests of the patient, the health care system, and society. Pharmacoeconomics can be applied to any therapeutic area like hospital pharmacy, using a variety of application strategies. As the healthcare sector is progressing day by day the need to develop Pharmacoeconomics area is must. Healthcare sector is not just a small area but it became an industry now. It has more dimensions to explore. So, main goal of this article was to explain it with in a cumulative way by mentioning two examples- where the first one is direct cost that outlays money and then is indirect cost for the productivity effect. Patients also get benefit out of Pharmacoeconomics findings. Pharmacoeconomics research should be strongly supported in a country like India where majority of health care spending is done by the patient’s themselves. Keywords: Pharmacoeconomics, ECHO Model, Pharmacist, Pharmacoeconomic evaluation, Healthcare Sector, Pharmaceutical Policy, Drug Commercialization, Cost Utility Analysis, Cost Benefit Analysis, Cost of illness Analysis, Cost Minimization Analysis.

The present research work was an attempt to develop, evaluate matrix-type transdermal therapeutic system containing lornoxicam with hydrophilic polymer (HPMC E-5) and turmeric oil (leaf extract) by the solvent evaporation technique. The turmeric oil has been used for two reasons, one is to see whether it act as natural penetration enhancer (replacing chemical enhancers) and also to compare the anti-inflammatory synergism between the drug and the oil itself. The anti-inflammatory activity of turmeric oil has been well documented. The physicochemical compatibility of the drug, polymers and oil was studied by infrared spectroscopy. The results suggested no physicochemical incompatibility between them. Five transdermal patch formulations (F1 to F5) consists of HPMC E5 (300 mg fixed) and turmeric oil in the concentrations 3%, 4%, 5%, 6% and 7% respectively were prepared. All formulations carried 10% w/v of Polyethylene glycol as plasticizer in dichloromethane and methanol (4:1) as solvent system. The prepared transdermal patches were evaluated for in vitro release, moisture absorption, moisture loss and mechanical properties. The diffusion studies were performed by using modified Franz diffusion cells. The formulation, F3 showed maximum release 97.56% as compared to patch without any penetration enhancer (58.83%).The synergistic activity has been determined by Carrageenan induced rat paw edema test and the results have confirmed the synergistic activity between the drug and turmeric oil. The developed transdermal patches may increase the efficacy of lornoxicam for the therapy of arthritis and other painful muscular conditions. Keywords: Transdermal system, HPMC, Turmeric oil, penetration enhancer, Synergistic activity.