1. Consistency and plausibility in epidemiologic analysis: application to breast cancer in relation to use of oral contraceptives.
- Author
-
Schlesselman JJ, Stadel BV, Murray P, Wingo PA, and Rubin GL
- Subjects
- Adult, Age Factors, Breast Neoplasms chemically induced, Contraceptives, Oral administration & dosage, Dose-Response Relationship, Drug, Epidemiologic Methods, Female, Humans, Menarche, Middle Aged, Parity, Risk Factors, Smoking adverse effects, Time Factors, Breast Neoplasms epidemiology, Contraceptives, Oral adverse effects
- Abstract
Consistency and plausibility are fundamental criteria for judging cause and effect from observational studies. They are applied here to the interpretation of data from a population-based case-control study of oral contraceptives and breast cancer. A preliminary analysis of oral contraceptive use in young nulliparous women, who had no family history of either breast cancer or benign breast disease, showed a statistically significant dose-response, with long-term users (49 months or more) having an apparent 4-fold elevation in risk of early breast cancer. Further analyses, however, revealed striking inconsistencies which were biologically implausible. These effectively undermine cause and effect as an explanation for the initial finding.
- Published
- 1987
- Full Text
- View/download PDF