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Smoking is one of the factors that can affect serum glucose in patients with type 1 diabetes (T1DM). Control of T1DM is associated with achieving glycated hemoglobin [HbA1c] levels of approximately 7%, which leads to reduced long-term cardiovascular risk. Thyroid hormones can also affect blood sugar levels. Therefore, appropriate control of diabetes can reduce the risk of developing thyroid disorders and vice versa. The aim of the study is to determine whether smoking affects glycemic control and thyroid function in established type 1 diabetes mellitus (T1DM). Materials and methods: A heterogeneous group of 73 patients aged 39±13 years were examined: men 49 (65.3%), women 24 (32%) with T1DM upon admission to the endocrinology department "St. Georgi" (Plovdiv); smokers 25; non-smokers 48. The following were investigated: blood glucose profile (BGP): serum glucose (mmol/L) at 6, 12, 17, 21, 24 hours; HBA1c (%); FT4 pmol/L; TSH mIU/L; TC: total cholesterol mmol/L; HDL-C mmol/L; LDL-C mmol/L; TAG mmol/L; BMI kg/m2 on admission to the ward. Results: In smokers compared to non-smokers, we found statistically significant, p<0.05: increased fasting serum glucose at 6 hours (15.59±6 mmol/L vs 9.67±3.3 mmol/L); decreased BMI (23.21±4.62 kg/m2 vs 26.16±4.79 kg/m2); HDL-C (1.05±0.35 mmol/L vs 1.57±0.43 mmol/L); as well as increased TSH (1.84±0.99 mIU/L vs 0.85±0.94 mIU/L). HBA1c at admission to the clinic showed no significant difference in smokers compared to non-smokers (9.15±1.66% vs. 10.07±1.98%, p=0.574). Conclusion: Smoking worsens glycemic control and thyroid function in patients with T1DM. [ABSTRACT FROM AUTHOR]

Wounds are among the most common skin diseases. They are formed after tissue injury and result in severe damage to the epidermis. The application of plants for wound healing is not only a cheap and accessible way of treatment, but also provides a reliable natural resource of medicinal substances with fewer side effects. Biologically active substances such as alkaloids, essential oils, flavonoids, tannins and phenolic compounds demonstrate a wide spectrum of action: wound healing, anti-inflammatory, antibacterial and antioxidant effects. This review article examines the chemical composition of three plants - Calendula officinalis, Marrubium vulgare, Vitis vinifera and the signal transduction in skin wound healing. Studies have shown that they have a strong antioxidant effect, hemostatic activity, powerful vasoconstrictor effect, pro-angiogenic and cell-protective effects. Because of the mentioned benefits of these plants, more scientific research and well-designed clinical trials are needed to establish their wider use in wound treating medicaments. [ABSTRACT FROM AUTHOR]