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When patients need to be for infusion at home, there is no central control server in hospital, and it is not possible to add additional monitoring equipment; at the same time, there may not be a special person to care for patients. The infusion monitoring communication model of smart home based on coloured Petri net, which is proposed in this paper, can use smart mobile phone to construct an adaptive infusion monitoring system at home. The model can make infusion alarm module automatically search for smart mobile phone terminals in a WiFi network, complete the search, identification, monitoring and other functions. It will constitute a smart phone infusion monitoring network so that infusion online monitoring could effectively be completed at home without adding additional equipment. The simulation result shows that regardless of whether there is a packet loss, as long as there is a smart mobile phone terminal and the corresponding infusion alarm module in the network, the model can make the infusion alarm module to realize automatic search function and infusion monitoring function, and provide better medical service for the smart home.