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Your search keyword '"Seganti, Giulio"' showing total 3 results
Start Over Author "Seganti, Giulio" Publisher british medical association
3 results on '"Seganti, Giulio"'

1. Procalcitonin in detecting neonatal nosocomial sepsis.

Author

Bambino Gesù Children’s Hospital – (Italy) Roma - Department of Medical and Surgical Neonatology, Auriti, Cinzia, Fiscarelli, Ersilia, Ronchetti, Maria Paola, Argentieri, Marta, Marrocco, Gabriella, Quondamcarlo, Anna, Seganti, Giulio, Bagnoli, Francesco, Buonocore, Giuseppe, Serra, Giovanni, Bacolla, Gianfranco, Mastropasqua, Savino, Mari, Annibale, Corchia, Carlo, Prencipe, Giusi, Piersigilli, Fiammetta, Ravà, Lucilla, Di Ciommo, Vincenzo, Bambino Gesù Children’s Hospital – (Italy) Roma - Department of Medical and Surgical Neonatology, Auriti, Cinzia, Fiscarelli, Ersilia, Ronchetti, Maria Paola, Argentieri, Marta, Marrocco, Gabriella, Quondamcarlo, Anna, Seganti, Giulio, Bagnoli, Francesco, Buonocore, Giuseppe, Serra, Giovanni, Bacolla, Gianfranco, Mastropasqua, Savino, Mari, Annibale, Corchia, Carlo, Prencipe, Giusi, Piersigilli, Fiammetta, Ravà, Lucilla, and Di Ciommo, Vincenzo

Abstract

OBJECTIVE: To investigate the accuracy of procalcitonin (PCT) as a diagnostic marker of nosocomial sepsis (NS) and define the most accurate cut-off to distinguish infected from uninfected neonates. SETTING: Six neonatal intensive care units (NICUs). PATIENTS: 762 neonates admitted to six NICUs during a 28-month observational study for whom at least one serum sample was taken on admission. MAIN OUTCOME MEASURES: Positive and negative predictive values at different PCT cut-off levels. RESULTS: The overall probability of an NS was doubled or more if PCT was >0.5 ng/ml. In very-low-birth-weight (VLBW) infants, a cut-off of >2.4 ng/ml gave a positive predictive value of NS near to 50% with a probability of a false-positive diagnosis of NS in about 10% of the patients. CONCLUSIONS: In VLBW neonates, a serum PCT value >2.4 ng/ml prompts early empirical antibiotic therapy, while in normal-birth-weight infants, a PCT value ≤2.4 ng/ml carries a low risk of missing an NS.

Published
2012

2. Nerve blockade as a therapeutic option in severe neonatal arterial ischaemia.

Author

Bambino Gesù Children’s Hospital – (Italy) Roma - Department of Medical and Surgical Neonatology, Piersigilli, Fiammetta, Di Pede, Alessandra, Dotta, Andrea, Auriti, Cinzia, Laviani Mancinelli, Raoul, Seganti, Giulio, Corchia, Carlo, Bambino Gesù Children’s Hospital – (Italy) Roma - Department of Medical and Surgical Neonatology, Piersigilli, Fiammetta, Di Pede, Alessandra, Dotta, Andrea, Auriti, Cinzia, Laviani Mancinelli, Raoul, Seganti, Giulio, and Corchia, Carlo

Abstract

We report the use of regional nerve blockade in the management of arterial limb ischaemia. A female infant weighing 815 g was born spontaneously at 26 weeks’ gestation. At birth the baby required resuscitation with endotracheal intubation. Soon after birth she underwent arterial blood gas analysis by direct puncture of the right radial artery. [...]

Published
2008

3. Procalcitonin in detecting neonatal nosocomial sepsis.

Author

Auriti C, Fiscarelli E, Ronchetti MP, Argentieri M, Marrocco G, Quondamcarlo A, Seganti G, Bagnoli F, Buonocore G, Serra G, Bacolla G, Mastropasqua S, Mari A, Corchia C, Prencipe G, Piersigilli F, Ravà L, and Di Ciommo V

Subjects
Calcitonin Gene-Related Peptide, Humans, Infant, Newborn, Infant, Very Low Birth Weight, Intensive Care Units, Neonatal, Likelihood Functions, ROC Curve, Sensitivity and Specificity, Calcitonin blood, Cross Infection diagnosis, Protein Precursors blood, Sepsis diagnosis
Abstract

Objective: To investigate the accuracy of procalcitonin (PCT) as a diagnostic marker of nosocomial sepsis (NS) and define the most accurate cut-off to distinguish infected from uninfected neonates., Setting: Six neonatal intensive care units (NICUs)., Patients: 762 neonates admitted to six NICUs during a 28-month observational study for whom at least one serum sample was taken on admission., Main Outcome Measures: Positive and negative predictive values at different PCT cut-off levels., Results: The overall probability of an NS was doubled or more if PCT was >0.5 ng/ml. In very-low-birth-weight (VLBW) infants, a cut-off of >2.4 ng/ml gave a positive predictive value of NS near to 50% with a probability of a false-positive diagnosis of NS in about 10% of the patients., Conclusions: In VLBW neonates, a serum PCT value >2.4 ng/ml prompts early empirical antibiotic therapy, while in normal-birth-weight infants, a PCT value ≤2.4 ng/ml carries a low risk of missing an NS.

Published
2012
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