7 results on '"L. Olbe"'
Search Results
2. Effect of fundic distension on gastric acid secretion in man.
- Author
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Grötzinger U, Bergegårdh S, and Olbe L
- Subjects
- Adult, Dilatation, Humans, Infusions, Parenteral, Male, Middle Aged, Pentagastrin pharmacology, Stomach drug effects, Duodenal Ulcer physiopathology, Gastric Juice metabolism, Stomach physiopathology
- Abstract
The effect of distension of the fundus and body of the stomach on gastric acid secretion was studied in 26 patients with duodenal ulcer and six healthy subjects. Graded distension produced by inflating a rubber balloon to volumes of 150, 300, and 600 ml resulted in significant sequential increments of acid output. The secretory response outlasted stimulation by at least one hour. In both groups of subjects, the highest acid output obtainable with fundic distension amounted to just above 50% of the maximum secretory response evoked by intravenous infusion of pentagastrin. A significant correlation was found between the peak secretory rates observed during fundic distension and after pentagastrin stimulation. It is concluded that distension of the oxyntic gland area in man is a potent stimulus for gastric secretion of acid and that patients with duodenal ulcer are no more sensitive to this stimulus than healthy subjects.
- Published
- 1977
- Full Text
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3. Origin of gastrin liberated by gastrin releasing peptide in man.
- Author
-
Lundell L, Lindstedt G, and Olbe L
- Subjects
- Adult, Aged, Dose-Response Relationship, Drug, Duodenum physiology, Gastrectomy, Gastrin-Releasing Peptide, Humans, Hydrogen-Ion Concentration, Middle Aged, Pancreatectomy, Pyloric Antrum physiology, Gastrins blood, Peptides pharmacology
- Abstract
Gastrin release induced by gastrin releasing peptide (GRP) in man has been studied in patients before and after complete resection of the antrum and duodenal bulb, as well as after pancreaticoduodenectomy according to Whipple. Studies in healthy subjects showed that 400 pmol/kg an hour of GRP induced a maximal release of gastrin. Infusion of this dose of GRP after a complete resection of the antrum and duodenal bulb induced a small, but significant increase in gastrin concentrations. After pancreaticoduodenectomy, however, GRP infusion had no effect on serum gastrin concentrations. In patients previously subjected to an incomplete antrectomy, GRP infusion was followed by a gastrin response considerably higher than after a complete antrectomy. Our results would suggest that GRP is capable of releasing gastrin predominantly from the antrum and the duodenal bulb, but also a small amount of gastrin from the remaining part of the duodenum. Gastrin releasing peptide infusion and determination of gastrin release may be of clinical significance in showing remaining significant gastrin pools in patients with recurrent ulceration after previous gastric resections.
- Published
- 1987
- Full Text
- View/download PDF
4. Effect of proximal gastric vagotomy and anticholinergics on the acid and gastrin responses to sham feeding in duodenal ulcer patients.
- Author
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Stenquist B, Rehfeld JF, and Olbe L
- Subjects
- Adult, Aged, Atropine pharmacology, Benzilates pharmacology, Depression, Chemical, Duodenal Ulcer blood, Duodenal Ulcer surgery, Eating, Humans, Insulin pharmacology, Male, Middle Aged, Pentagastrin, Pyrrolidines pharmacology, Stomach innervation, Duodenal Ulcer physiopathology, Gastric Juice metabolism, Gastrins blood, Parasympatholytics pharmacology, Vagotomy
- Abstract
Plasma gastrin concentrations and gastric acid output after modified sham feeding were determined in 20 duodenal ulcer patients. Sham feeding produced an acid response corresponding to 40-68% of the maximal acid output after pentagastrin stimulation, with no significant increase of plasma gastrin concentrations. In eight patients proximal gastric vagotomy almost abolished the acid responses to both insulin hypoglycaemia and sham feeding. Sham feeding in the vagotomised patients did not change the gastrin concentrations in plasma. After pretreatment with benzilonium, an anticholinergic with minimal central nervous effects, plasma gastrin concentrations increased after sham feeding. The study confirms that sham feeding is a poor stimulus for gastrin release in duodenal ulcer patients and supports a cholinergic inhibition of gastrin release. Intravenous injection of benzilonium bromide in a dose close to 70 micrograms/kg, and atropine in the low dose of 30 micrograms/kg inhibited the acid response to sham feeding by about 65%. Atropine in a dose of 50 micrograms/kg virtually abolished the acid sham feeding response, possibly owing to ganglionic or central nervous blockade. Vagal activation of the acid secretory glands does not seem to involve a purely cholinergic neurotransmission.
- Published
- 1979
- Full Text
- View/download PDF
5. Effect of atropine and proximal gastric vagotomy on the acid response to fundic distension in man.
- Author
-
Grötzinger U, Bergegårdh S, and Olbe L
- Subjects
- Adult, Aged, Dilatation, Humans, Male, Middle Aged, Pentagastrin pharmacology, Stomach drug effects, Atropine pharmacology, Duodenal Ulcer physiopathology, Gastric Juice metabolism, Stomach physiopathology, Vagotomy
- Abstract
In four healthy subjects and in 12 patients with duodenal ulcer (DU), graded balloon distension of the gastric fundus and body caused increments in acid output related to the distension volumes. The mean peak distension response amounted to about 50% of the mean peak acid output (PAOpg) evoked by intravenous infusion of pentagastrin in a dose of 300 microng/h, eliciting maximum observed secretory response. During distension with the largest balloon volume, 1-0 mg atropine injected intravenously significantly depressed the acid secretory rate, the median inhibition amounting to about 80%. In two patients with DU, 2-5 mg atropine completely abolished acid secretion during fundic distension. In nine subjects with DU, complete proximal gastric vagotomy profoundly depressed the secretory responses to graded fundic distension, eliminating the acid response to the smallest balloon volume used. A slight, but significant, response to the largest distension volume persisted after complete vagotomy. Incomplete proxomal gastric vagotomy was found to reduce only moderately the distension responses in five patients, and the peak acid response to fundic distension as related to PAOpg remained unchanged. In conclusion, distension of the gastric fundus and body in man stimulates acid secretion by means of an atropine-sensitive, presumably cholinergic, reflex mechanism and the findings after vagotomy are in agreement with the concept that this reflex mechanism is conveyed by both short intramural and long vagovagal pathways.
- Published
- 1977
- Full Text
- View/download PDF
6. Effect of omeprazole--a gastric proton pump inhibitor--on pentagastrin stimulated acid secretion in man.
- Author
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Lind T, Cederberg C, Ekenved G, Haglund U, and Olbe L
- Subjects
- Adult, Benzimidazoles administration & dosage, Benzimidazoles blood, Dose-Response Relationship, Drug, Gastric Acidity Determination, Humans, Male, Omeprazole, Pentagastrin pharmacology, Secretory Rate drug effects, Benzimidazoles pharmacology, Gastric Acid metabolism, Pentagastrin antagonists & inhibitors
- Abstract
The effect of oral omeprazole on pentagastrin stimulated gastric acid secretion was studied in 11 healthy subjects. Doses of 20-80 mg produced dose dependent inhibition of acid secretion, with total suppression at the highest dose. Omeprazole was absorbed and eliminated from plasma rapidly and the inhibitory effect was related to the area under the plasma concentration time curve. The duration of action was long and single doses of 20 and 40 mg reduced acid secretion significantly for one and three days, respectively. Omeprazole in a dose of 15 mg given once daily for five days, suppressed acid secretion continuously, the inhibitory effect stabilising after three days at a predose inhibition of about 30% and a postdose inhibition of about 80%.
- Published
- 1983
- Full Text
- View/download PDF
7. Fat inhibition of gastric acid secretion in duodenal ulcer patients before and after proximal gastric vagotomy.
- Author
-
Kihl B and Olbe L
- Subjects
- Adult, Depression, Chemical, Female, Gastric Mucosa drug effects, Humans, Insulin pharmacology, Male, Middle Aged, Pentagastrin pharmacology, Postoperative Period, Preoperative Care, Secretory Rate drug effects, Duodenal Ulcer physiopathology, Gastric Acid metabolism, Oleic Acids pharmacology, Vagotomy, Vagotomy, Proximal Gastric
- Abstract
In seven duodenal ulcer patients the effect of intraduodenal infusion of 20 ml oleic acid on submaximal gastric acid secretion stimulation by a continuous pentagastrin infusion was evaluated before and after proximal gastric vagotomy. In the control tests 20 ml of saline was given. Before vagotomy, oleic acid evoked a significant inhibition of gastric acid secretion of 25% compared with the controls. This inhibition was abolished after proximal gastric vagotomy. The difference in inhibition before and after vagotomy was significant (P=0.01). It is concluded that the vagus nerve in man plays a decisive role in duodenal fat inhibition of gastric acid secretion.
- Published
- 1980
- Full Text
- View/download PDF
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