1. A functional polymorphism of the microRNA-146a gene is associated with susceptibility to drug-resistant epilepsy and seizures frequency
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Wanwen Cheng, Lili Cui, Haihong Zhou, Wandong Liang, Yu Liu, Zhou Liu, Hua Tao, Beichu Chen, Tingting Liu, Zhien Xu, Keshen Li, Lifen Yao, Bin Zhao, You Li, Guoda Ma, Yujie Cai, and Yan Wang
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Adult ,Male ,Drug Resistant Epilepsy ,Adolescent ,Genotype ,Clinical Neurology ,Drug-resistant epilepsy ,Single-nucleotide polymorphism ,MicroRNA-146a ,Seizures frequency ,Biology ,Bioinformatics ,Polymorphism, Single Nucleotide ,Epilepsy ,Young Adult ,Gene Frequency ,Seizures ,Genetic predisposition ,medicine ,SNP ,Humans ,Genetic Predisposition to Disease ,Allele ,Polymorphism ,Child ,Genetic Association Studies ,Aged ,Neurologic Examination ,Electroencephalography ,General Medicine ,Middle Aged ,medicine.disease ,Exact test ,MicroRNAs ,Neurology ,Female ,Neurology (clinical) - Abstract
PurposeEpilepsy is the third most common chronic brain disorder and is characterized by an enduring predisposition for seizures. Recently, a growing body of evidence has suggested that microRNA-146a (miR-146a) is upregulated in the brains of epilepsy patients and of mouse models; furthermore, miR-146a may be involved in the development and progression of seizures through the regulation of inflammation and immune responses. In this report, we performed a case–control study to analyze the relationship between the two potentially functional single nucleotide polymorphisms (SNPs) of the miR-146a gene (rs2910464 and rs57095329) and the risk of epilepsy in a Chinese population comprising 249 cases and 249 healthy controls.MethodOur study comprised 249 epilepsy patients and 249 healthy controls in two regions of China. The DNA was genotyped using the ABI PRISM SNapShot method. The statistical analysis was estimated using the chi-square test or Fisher's exact test.ResultsOur results indicated a significant association between the rs57095329 SNP of the miR-146a gene and the risk of drug resistant epilepsy (DRE) (genotypes, p=0.0258 and alleles, p=0.0108). Moreover, the rs57095329 A allele was found to be associated with a reduced risk of seizures frequency in DRE patients (all p
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