1. Prognostic implications of left atrial dilation in aortic regurgitation due to bicuspid aortic valve
- Author
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Federico Fortuni, Arturo Evangelista, Michael Liang, Laura Galian-Gay, Victoria Delgado, Philippe Pibarot, A Gonzalez-Gomez, Fausto J. Pinto, Edgar Lik Wui Tay, Steele C Butcher, William K.F. Kong, Francesca Prevedello, Tiong-Cheng Yeo, Mylène Shen, Joseph B. Selvanayagam, Ana G. Almeida, Kian Keong Poh, Nina Ajmone Marsan, Marcin Fijałkowski, Rebecca Perry, Arnold C.T. Ng, José Luis Zamorano, Jeroen J. Bax, E. Mara Vollema, Miriam Shanks, Bogdan A. Popescu, Butcher, Steele C., Fortuni, Federico, Kong, William, Vollema, E. Mara, Perry, Rebecca, Delgado, Victoria, and Repositório da Universidade de Lisboa
- Subjects
Male ,medicine.medical_specialty ,Bicuspid aortic valve ,Aortic regurgitation ,Regurgitation (circulation) ,Bicuspid Aortic Valve Disease ,Left atrial ,Internal medicine ,medicine.artery ,Ascending aorta ,Humans ,Medicine ,Cardiac skeleton ,Retrospective Studies ,Ejection fraction ,business.industry ,Sinotubular Junction ,Prognosis ,medicine.disease ,Dilatation ,Aortic valve insufficiency ,Echocardiography ,Aortic Valve ,Aortic valve surgery ,Cardiology ,cardiovascular system ,Female ,Cardiology and Cardiovascular Medicine ,business ,Dilatation, Pathologic - Abstract
© Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ., Objective: To investigate the prognostic value of left atrial volume index (LAVI) in patients with moderate to severe aortic regurgitation (AR) and bicuspid aortic valve (BAV). Methods: 554 individuals (45 (IQR 33-57) years, 80% male) with BAV and moderate or severe AR were selected from an international, multicentre registry. The association between LAVI and the combined endpoint of all-cause mortality or aortic valve surgery was investigated with Cox proportional hazard regression analyses. Results: Dilated LAVI was observed in 181 (32.7%) patients. The mean indexed aortic annulus, sinus of Valsalva, sinotubular junction and ascending aorta diameters were 13.0±2.0 mm/m2, 19.4±3.7 mm/m2, 16.5±3.8 mm/m2 and 20.4±4.5 mm/m2, respectively. After a median follow-up of 23 (4-82) months, 272 patients underwent aortic valve surgery (89%) or died (11%). When compared with patients with normal LAVI (
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- 2021