1. Clinical importance of baseline measurement in [sup 13]C-urea breath test.
- Author
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Yang, J.C., Kuo, Y.N., Lee, S.C., Yang, T.H., Twu, S.J., and Wang, T.H.
- Subjects
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HELICOBACTER pylori infections , *BREATH tests , *UREA - Abstract
Introduction: Some investigators have suggested that the H. pylori infective status can be determined from a single 30-min post-dose breath sample of the [sup 13]C-urea breath test ([sup 13]C-UBT). The aim of this study was to evaluate the clinical importance of baseline measurement in [sup 13]C-UBT. Methods: Totally, 663 adults (age 20-80) with dyspepsia and 1052 children (age 6-14) in an epidemiological investigation were enrolled. The [sup 13]C-UBT was performed according to our standard protocol in which baseline breath sample was collected after 8 hours' fasting, after which the subject drank a solution of 100mg [sup 13]C-urea in 50 ml distilled water. The other breath sample was collected at 30 min post dosing. A positive test was defined as an increase in the ratio of 5 per mil over baseline. A questionnaire about dietary content was filled by each case. The δ[sup 13]C values of various Taiwanese foods were determined by continuous-flow isotope ratio mass spectrometory. Results: The Taiwanese food could be divided into two groups: the higher δ[sup 13]C value group (range from -10.4 to -20.6 per mil), and the lower δ[sup 13]C value group (range from -22.3 to -29.3 per mil). The mean δ[sup 13]C value of baseline measurement of adults was significant lower than that of children (-24.6±1.3 vs. -20.9±1.2; p < 0.01). This is probably because the Taiwanese children tend to consume more sugar, meat, and fat. If only a single 30-min sample was adopted to determine the H. pylori status, a further 5% false-positive and 1% false-negative results would occur. Conclusions: The baseline measurement in [sup 13]C-UBT for detection of H. pylori infection should not be omitted. There is variation in meanδ[sup 13]C value of baseline measurement in different age group and geographic area. These values may also be used as a dietary guideline for patients in the prevention of various diseases. [ABSTRACT FROM AUTHOR]
- Published
- 2002