15 results on '"Vliegen, Hubert W"'
Search Results
2. Sacubitril/valsartan in the treatment of systemic right ventricular failure.
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Zandstra, Tjitske E., Nederend, Marieke, Jongbloed, Monique R. M., Kiès, Philippine, Vliegen, Hubert W., Bouma, Berto J., Tops, Laurens F., Schalij, Martin J., and Egorova, Anastasia D.
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TRANSPOSITION of great vessels ,VALSARTAN ,ENTRESTO ,COGNITIVE ability ,QUALITY of life ,AMINOBUTYRIC acid ,ECHOCARDIOGRAPHY ,RESEARCH ,COMBINATION drug therapy ,RIGHT heart ventricle ,RESEARCH methodology ,BIPHENYL compounds ,RETROSPECTIVE studies ,MEDICAL cooperation ,EVALUATION research ,TREATMENT effectiveness ,COMPARATIVE studies ,HEART physiology ,ANGIOTENSIN receptors ,HEART failure ,LONGITUDINAL method - Abstract
Objective: Pharmacological options for patients with a failing systemic right ventricle (RV) in the context of transposition of the great arteries (TGA) after atrial switch or congenitally corrected TGA (ccTGA) are not well defined. This study aims to investigate the feasibility and effects of sacubitril/valsartan treatment in a single-centre cohort of patients.Methods: Data on all consecutive adult patients (n=20, mean age 46 years, 50% women) with a failing systemic RV in a biventricular circulation treated with sacubitril/valsartan in our centre are reported. Patients with a systemic RV ejection fraction of ≤35% who were symptomatic despite treatment with β-blocker and ACE-inhibitor/angiotensin II receptor-blockers were started on sacubitril/valsartan. This cohort underwent structural follow-up including echocardiography, exercise testing, laboratory investigations and quality of life (QOL) assessment.Results: Six-month follow-up data were available in 18 out of 20 patients, including 12 (67%) patients with TGA after atrial switch and 6 (33%) patients with ccTGA. N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) decreased significantly (950-358 ng/L, p<0.001). Echocardiographic systemic RV fractional area change and global longitudinal strain showed small improvements (19%-22%, p<0.001 and -11% to -13%, p=0.014, respectively). The 6 min walking distance improved significantly from an average of 564 to 600 m (p=0.011). The QOL domains of cognitive function, sleep and vitality improved (p=0.015, p=0.007 and p=0.037, respectively).Conclusions: We describe the first patient cohort with systemic RV failure treated with sacubitril/valsartan. Treatment appears feasible with improvements in NT-pro-BNP and echocardiographic function. Our positive results show the potential of sacubitril/valsartan for this patient population. [ABSTRACT FROM AUTHOR]- Published
- 2021
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3. Non-invasive early exclusion of chronic thromboembolic pulmonary hypertension after acute pulmonary embolism: the InShape II study.
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Boon, Gudula J. A. M., Ende-Verhaar, Yvonne M., Bavalia, Roisin, El Bouazzaoui, Lahassan H., Delcroix, Marion, Dzikowska-Diduch, Olga, Huisman, Menno V., Kurnicka, Katarzyna, Mairuhu, Albert T. A., Middeldorp, Saskia, Pruszczyk, Piotr, Ruigrok, Dieuwertje, Verhamme, Peter, Vliegen, Hubert W., Noordegraaf, Anton Vonk, Vriend, Joris W. J., Klok, Frederikus A., Vonk Noordegraaf, Anton, and InShape II study group
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PULMONARY hypertension ,PULMONARY embolism ,DELAYED diagnosis ,THROMBOEMBOLISM ,QUALITY-adjusted life years ,ECHOCARDIOGRAPHY ,SYMPTOMS - Abstract
Background: The current diagnostic delay of chronic thromboembolic pulmonary hypertension (CTEPH) after pulmonary embolism (PE) is unacceptably long, causing loss of quality-adjusted life years and excess mortality. Validated screening strategies for early CTEPH diagnosis are lacking. Echocardiographic screening among all PE survivors is associated with overdiagnosis and cost-ineffectiveness. We aimed to validate a simple screening strategy for excluding CTEPH early after acute PE, limiting the number of performed echocardiograms.Methods: In this prospective, international, multicentre management study, consecutive patients were managed according to a screening algorithm starting 3 months after acute PE to determine whether echocardiographic evaluation of pulmonary hypertension (PH) was indicated. If the 'CTEPH prediction score' indicated high pretest probability or matching symptoms were present, the 'CTEPH rule-out criteria' were applied, consisting of ECG reading and N-terminalpro-brain natriuretic peptide. Only if these results could not rule out possible PH, the patients were referred for echocardiography.Results: 424 patients were included. Based on the algorithm, CTEPH was considered absent in 343 (81%) patients, leaving 81 patients (19%) referred for echocardiography. During 2-year follow-up, one patient in whom echocardiography was deemed unnecessary by the algorithm was diagnosed with CTEPH, reflecting an algorithm failure rate of 0.29% (95% CI 0% to 1.6%). Overall CTEPH incidence was 3.1% (13/424), of whom 10 patients were diagnosed within 4 months after the PE presentation.Conclusions: The InShape II algorithm accurately excluded CTEPH, without the need for echocardiography in the overall majority of patients. CTEPH was identified early after acute PE, resulting in a substantially shorter diagnostic delay than in current practice. [ABSTRACT FROM AUTHOR]- Published
- 2021
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4. Long-term outcome after atrial correction for transposition of the great arteries.
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Couperus, Lotte E., Vliegen, Hubert W., Zandstra, Tjitske E., Kiès, Philippine, Jongbloed, Monique R. M., Holman, Eduard R., Zeppenfeld, Katja, Hazekamp, Mark G., Schalij, Martin J., and Scherptong, Roderick W. C.
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TRANSPOSITION of great vessels ,VENTRICULAR arrhythmia ,SUPRAVENTRICULAR tachycardia ,HEART failure - Abstract
Objective: This study assessed adult survival and morbidity patterns in patients who underwent atrial correction according to Mustard or Senning for transposition of the great arteries (TGA).Methods: In 76 adult patients with TGA (59% male) after atrial correction, long-term survival and morbidity were investigated in three periods: early (<15 years postoperatively), midterm (15-30 years postoperatively) and late (>30 years postoperatively).Results: The Mustard technique was performed in 41 (54%) patients, and the Senning technique was performed in 35 (46%) patients aged 3.1 (IQR: 2.1-3.8) and 1.0 (IQR: 0.6-3.1; p<0.01) years, respectively. Adult survival was 82% at 39.7 (IQR: 35.9-42.4) years postoperatively and exceeded 50 years in four patients. Supraventricular tachycardia (SVT) occurred in 51% of patients. The incidences of ventricular arrhythmia (0%, 8% and 13%; p<0.01), heart failure (0%, 5% and 19%; p<0.01) and surgical reinterventions (0%, 5% and 11%; p=0.01) increased from early to late follow-up. At last follow-up, RV function was depressed in 31 (46%) patients, and New York Heart Association functional class was ≥2 in 34 (48%) patients. Bradyarrhythmia, SVT and ventricular arrhythmia were associated with depressed RV function (OR: 4.47, 95% CI 1.50 to 13.28, p<0.01; OR: 3.74, 95% CI 1.26 to 11.14, p=0.02; OR: 14.40, 95% CI 2.80 to 74.07, p<0.01, respectively) and worse functional capacity (OR: 2.10, 95% CI 0.75 to 5.82, p=0.16; OR: 2.87, 95% CI 1.06 to 7.81, p=0.04; OR: 8.47, 95% CI 1.70 to 42.10, p<0.01, respectively).Conclusions: In adult patients with TGA, survival was 82% at 39.7 (IQR: 35.9-42.4) years after atrial correction. Morbidity was high and included SVT as most frequent adverse event. Ventricular arrhythmias, heart failure and surgical reinterventions were common during late follow-up. Adverse events were associated with depressed right ventricle function and reduced functional class. [ABSTRACT FROM AUTHOR]- Published
- 2019
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5. QRS fragmentation is superior to QRS duration in predicting mortality in adults with tetralogy of Fallot.
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Bokma, Jouke P., Winter, Michiel M., Vehmeijer, Jim T., Vliegen, Hubert W., van Dijk, Arie P., van Melle, Joost P., Meijboom, Folkert J., Post, Martijn C., Zwinderman, Aeilko H., Mulder, Barbara J. M., and Bouma, Berto J.
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TETRALOGY of Fallot ,FIBROSIS ,MORTALITY ,ELECTROCARDIOGRAPHY ,CONGENITAL heart disease ,PROGNOSIS ,DIAGNOSIS - Published
- 2017
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6. Coronary anatomy as related to bicuspid aortic valve morphology.
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Koenraadt, Wilke M. C., Tokmaji, George, DeRuiter, Marco C., Vliegen, Hubert W., Scholte, Arthur J. H. A., Siebelink, Hans Marc J., Groot, Adriana C. Gittenberger-de, de Graaf, Michiel A., Wolterbeek, Ron, Mulder, Barbara J., Bouma, Berto J., Schalij, Martin J., Jongbloed, Monique R. M., and Gittenberger-de Groot, Adriana C
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AORTIC valve ,MITRAL valve ,CORONARY arteries ,MORPHOLOGY ,CORONARY disease ,ANATOMY - Abstract
Objective: Variable coronary anatomy has been described in patients with bicuspid aortic valves (BAVs). This was never specified to BAV morphology, and prognostic relevance of coronary vessel dominance in this patient group is unclear. The purpose of this study was to evaluate valve morphology in relation to coronary artery anatomy and outcome in patients with isolated BAV and with associated aortic coarctation (CoA).Methods: Coronary anatomy was evaluated in 186 patients with BAV (141 men (79%), 51±14 years) by CT and invasive coronary angiography. Correlation of coronary anatomy was made with BAV morphology and coronary events.Results: Strictly bicuspid valves (without raphe) with left-right cusp fusion (type 1B) had more left dominant coronary systems compared with BAVs with left-right cusp fusion with a raphe (type 1A) (48% vs. 26%, p=0.047) and showed more separate ostia (28% vs. 9%, p=0.016). Type 1B BAVs had more coronary artery disease than patients with type 1A BAV (36% vs. 19%, p=0.047). More left dominance was seen in BAV patients with CoA than in patients without (65% vs. 24%, p<0.05).Conclusions: The incidence of a left dominant coronary artery system and separate ostia was significantly related to BAVs with left-right fusion without a raphe (type 1B). These patients more often had significant coronary artery disease. In patients with BAV and CoA, left dominancy is more common. [ABSTRACT FROM AUTHOR]- Published
- 2016
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7. Contemporary survival of adults with congenital heart disease.
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van der Bom, Teun, Mulder, Barbara J. M., Meijboom, Folkert J., van Dijk, Arie P. J., Pieper, Petronella G., Vliegen, Hubert W., Konings, Thelma C., Zwinderman, Aeilko H., Bouma, Berto J., Mulder, Barbara Jm, and van Dijk, Arie Pj
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CONGENITAL heart disease ,CARDIOVASCULAR surgery ,TISSUE wounds ,PULMONARY hypertension ,TERTIARY care ,HYPERTENSION risk factors ,CONGENITAL heart disease diagnosis ,AGE distribution ,LONGITUDINAL method ,PROGNOSIS ,REGRESSION analysis ,TIME ,LOGISTIC regression analysis ,ACQUISITION of data ,PROPORTIONAL hazards models ,KAPLAN-Meier estimator ,ODDS ratio ,THERAPEUTICS - Abstract
Background: Survival data that are applicable to the current population of adults with congenital heart disease (CHD) are not available.Objectives: Using an alternative survival analysis with age as the primary time scale, we assessed the contemporary survival of adult patients with CHD.Methods: Survival was assessed using prospective data of the national registry of adult patients with CHD of the Netherlands. Survival was stratified by severity and lesion, and compared with a standardised general population.Results: Mean age at inclusion was 37 years, and 49% of the study population was male. During a cumulative prospective follow-up of 90, 270 patient-years in 14, 327 patients, 535 deaths occurred. Median survival was 53.4 (95% CI 49.9 to 60.7), 75.4 (95% CI 72.9 to 79.1) and 84.1 (95% CI 81.9 to 87.0) years for patients with severe, moderate and mild lesions, respectively. Survival of most patients with mild lesions did not differ from the general population, while, as expected, survival of patients with severe and moderate lesions was substantially lower (<0.001).Conclusions: The present study gives insight in the contemporary survival of adults with CHD. This may aid patient counselling, timing of interventions and future research. [ABSTRACT FROM AUTHOR]- Published
- 2015
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8. Individualised prediction of pulmonary homograft durability in tetralogy of Fallot.
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Bokma, Jouke P., Winter, Michiel M., Oosterhof, Thomas, Vliegen, Hubert W., van Dijk, Arie P., Hazekamp, Mark G., Koolbergen, Dave R., Groenink, Maarten, Mulder, Barbara J. M., and Bouma, Berto J.
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Background In patients with repaired tetralogy of Fallot (rTOF), multiple reoperations or percutaneous interventions after pulmonary valve replacement (PVR) may be necessary due to limited homograft durability. However, data to guide individualised prediction of homograft durability remain scarce. The aim of this study was to provide risk models for RV to pulmonary artery homograft durability. Methods This retrospective multicentre study included consecutive patients with rTOF who had undergone PVR at an age of >12 years. Homograft dysfunction was defined as at least moderate pulmonary regurgitation (PR) or pulmonary stenosis (PS) (pressure gradient ≥36 mm Hg) as assessed by echocardiography. Reintervention was defined as percutaneous intervention or redo-PVR. Results A total of 153 patients with rTOF were included (62% male, mean age at PVR 31±11 years, pulmonary homograft 96%, follow-up 9.6 years (IQR 5.9, 13.3)). Average freedom from homograft dysfunction and reintervention after 10 years was 74% and 89%, respectively. In multivariable Cox proportional hazards analysis, postoperative PS ≥20 mm Hg (HR 6.52, 95% CI 3.09 to 13.7), postoperative PR ≥ grade 1 (HR 3.13, 95% CI 1.45 to 6.74) and age at PVR <18 years (HR 3.52, 95% CI 1.64 to 7.53) were independently predictive for homograft dysfunction. In patients without any risk factor, 10-year freedom from homograft dysfunction and reintervention was excellent (91% and 96%, respectively) in contrast to patients with ≥2 risk factors (25% and 73%, respectively). Conclusions Individualised prediction of homograft durability in patients with rTOF can be guided by early postoperative echocardiography. In adult patients without early postoperative PS or PR, homograft dysfunction and reintervention are unlikely to occur within 10 years, and follow-up may be less stringent. [ABSTRACT FROM AUTHOR]
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- 2015
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9. Severe tricuspid regurgitation is predictive for adverse events in tetralogy of Fallot.
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Bokma, Jouke P., Winter, Michiel M., Oosterhof, Thomas, Vliegen, Hubert W., van Dijk, Arie P., Hazekamp, Mark G., Koolbergen, Dave R., Groenink, Maarten, Mulder, Barbara J. M., and Bouma, Berto J.
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TRICUSPID valve ,AORTIC valve insufficiency ,ADVERSE health care events ,TETRALOGY of Fallot ,ECHOCARDIOGRAPHY ,PREOPERATIVE care - Abstract
Objective Patients with surgically repaired tetralogy of Fallot (rTOF) may develop functional tricuspid regurgitation (TR) due to annulus dilation. Guidelines suggest pulmonary valve replacement (PVR) in patients with rTOF with progressive TR, but data on clinical outcomes are lacking. Our objective was to determine whether TR was predictive for adverse events after PVR. Methods In this retrospective, multicenter cohort study, patients with rTOF who had undergone PVR after preoperative echocardiographic assessment of TR grade were included. Preoperative and postoperative imaging data and a composite of adverse clinical events (death, sustained ventricular tachycardia, heart failure, or supraventricular tachycardia) were collected. Multivariate Cox hazards regression analysis was used to determine which factors were predictive for adverse events after PVR. Results A total of 129 patients (61% men, age at PVR 32.9±10.4 years) were included. The composite endpoint occurred in 39 patients during 8.4±4.2 years of follow-up. In multivariate analysis, severe preoperative TR (HR 2.49, 95% CI 1.11 to 5.52), right ventricular end-systolic volume (HR 1.02/mL/mm², 95% CI 1.01 to 1.03) and age at PVR (HR 1.07/year, 95% CI 1.04 to 1.09) were predictive for adverse events. Early postoperative TR was not predictive for adverse events (p=0.96). In patients without any risk factor (age >40 years, right ventricular end-systolic volume >90 mL/m² or severe TR), 5-year event-free survival was 100% as compared with 61% in patients with two or three risk factors. Conclusions In patients with rTOF, severe preoperative TR was predictive for adverse events after PVR. Close surveillance is warranted in these patients irrespective of postoperative TR. [ABSTRACT FROM AUTHOR]
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- 2015
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10. Diagnosis and treatment of pulmonary hypertension.
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Haeck, Marlieke L. A. and Vliegen, Hubert W.
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PULMONARY hypertension diagnosis , *PULMONARY hypertension treatment , *HYPERPLASIA , *HEART valve diseases , *LUNG diseases , *ELECTROCARDIOGRAPHY , *PROSTACYCLIN , *ENDARTERECTOMY - Abstract
The article discusses pulmonary hypertension (PH) and its diagnosis and treatment. Topics discussed include several causes of Ph which include hyperplasia, Heart valve diseases and lung disease, diagnosis processes like electrocardiography, imaging and echocardiography and treatments for PH such as anticoagulation therapy, Prostacyclin drugs and pulmonary endarterectomy surgery.
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- 2015
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11. Persistent neo-aortic growth during adulthood in patients after an arterial switch operation.
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van der Bom, Teun, van der Palen, Roel L. F., Bouma, Berto J., van Veldhuisen, Sophie L., Vliegen, Hubert W., Konings, Thelma C., Zwinderman, Aeilko H., Blom, Nico A., Koolbergen, Dave R., Hazekamp, Mark G., and Mulder, Barbara J. M.
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AORTA surgery ,ECHOCARDIOGRAPHY ,HEART disease research ,MAGNETIC resonance imaging ,COMPUTED tomography - Abstract
Objective After the arterial switch operation (ASO), disproportional neo-aortic growth during childhood has been reported. Even though it has been suggested neoaortic dilation will stabilise in adulthood, data are lacking. The aim of this study was to assess the change in neo-aortic dimensions, prevalence of neo-aortic dilation >40 mm and long-term outcome in adults who underwent ASO in childhood. Methods All 116 ASO patients operated in a tertiary referral centre and born before 1995 were included. Of these, 83 (72%) survived to adulthood (>17 years) and six were lost to follow-up. Neo-aortic measurements performed in adulthood were collected from available echocardiographic, cardiovascular magnetic resonance and CT images. The time trend was analysed using a mixed model, adjusted for imaging modality. Results Clinical data with at least one measurement of the neo-aortic diameter were available in 77 (93%) adult patients and serial measurements in 65 (78%). At baseline (median age 18.1 years), mean neo-aortic diameter was 36±5 mm. Mean neo-aortic growth was 0.31 mm/year (p<0.001 compared with normal value 0.08 mm/year) and was linear over time. Freedom from neo-aortic dilation beyond a diameter of 40 mm was 23% at 28 years of age. During a mean clinical followup in adulthood of 7.2 years (IQR 4.0 to 10.1), 3 (4%) patients underwent neo-aortic replacement. No other neo-aortic complications occurred. Conclusions In early adulthood, neo-aortic growth was on average linear and did not stabilise over time. [ABSTRACT FROM AUTHOR]
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- 2014
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12. Prospective validation and assessment of cardiovascular and offspring risk models for pregnant women with congenital heart disease.
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Balci, Ali, Sollie-Szarynska, Krystyna M., van der Bijl, Antoinette G. L., Ruys, Titia P. E., Mulder, Barbara J. M., Roos-Hesselin, Jolien W., van Dijk, Arie P. J., Wajo, Elly M. C. J., Vliegen, Hubert W., Drenthen, Willem, Hillege, Hans L., Aarnoudse, Jan G., van Veldhuisen, Dirk J., and Pieper, Petronella G.
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PREGNANCY complications ,CONGENITAL heart disease ,HEART failure ,MISCARRIAGE ,NEONATAL death - Abstract
Objectives Adequate prepregnancy prediction of maternal cardiovascular and offspring risk is important for counselling and management of pregnancy in women with congenital heart disease (CHD). Therefore we performed a study to identify the optimal assessment strategy for estimating the risk of pregnancy in women with CHD. Methods In this prospective study, we determined the outcomes of 213 pregnancies in 203 women with CHD. The ZAHARA I (Zwangerschap bij Aangeboren HARtAfwijkingen I) and CARPREG (CARdiac disease in PREGnancy) risk scores were calculated for each pregnancy, as was the total number of cardiovascular (TPc) or offspring risk predictors (TPo) from these and other studies combined. Pregnancies were also classified according to the modified WHO classification of maternal cardiovascular risk and according to disease complexity (DC). Results Maternal cardiovascular events occurred during 22 pregnancies (10.3%). Offspring events occurred during 77 pregnancies in 81 children (37.3%). Cardiovascular and offspring event rates increased with higher risk scores, higher TPc or TPo, higher WHO class and greater DC. The highest area under the curve (AUC) for maternal cardiovascular risk was achieved by the WHO class (AUC: 0.77, p<0.0001). AUC for the ZAHARA I risk score was 0.71 (p=0.001), and for the CARPREG risk score 0.57 (p=0.32). All models performed insufficiently in predicting offspring events (AUC⩽0.6). Conclusions The WHO classification is the best available risk assessment model for estimating cardiovascular risk in pregnant women with CHD. None of the offspring prediction models perform adequately in our cohort. [ABSTRACT FROM AUTHOR]
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- 2014
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13. Long-term effect of pulmonary valve replacement on QRS duration in patients with corrected tetralogy of Fallot.
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Oosterhof, Thomas, Vliegen, Hubert W., Meijboom, Folkert J., Zwinderman, Aeilko H., Bouma, Berto, and Mulder, Barbara J. M.
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PULMONARY valve , *PATIENTS , *TETRALOGY of Fallot , *HEART valve surgery , *POSTOPERATIVE care , *HEALTH outcome assessment - Abstract
Objective: To analyse the long-term course of QRS duration after pulmonary valve replacement in patients with a previous correction for tetralogy of Fallot. Setting: Tertiary referral centres. Methods: In a retrospective study, 99 adult patients with tetralogy of Fallot, who had undergone a first pulmonary valve replacement late after initial total correction, were identified from the CONCOR (CONgenital CORvitia) registry. Computer-generated QRS durations were obtained from 12-lead electrocardiogram ECG reports in the medical records. A mixed linear regression model was used to analyse the course of QRS duration over time and to identify risk factors for increase in QRS duration over time. Composite end point was created from sudden cardiac death, ventricular tachycardia or implantable cardioverter-defibrillator discharge. Results: In total, 99 patients (57% men, mean (SD) age at pulmonary valve replacement 29 (11) years) with a median follow-up of 4.9 (0.1-16) years were analysed. In patients with preoperative QRS <120 ms, surgery caused no significant change in QRS duration (increase 1.3 (7.9) ms; p=0.65), and after surgery, QRS duration remained stable overtime (increase 0.0064(0.059) ms/year; p=0.98). By contrast, in patients with a preoperative ORS of 150-180 ms or QRS ⩾ 180 ms, surgery resulted in QRS shortening (mean decrease 9.9 (SE 4.3) ms, p=0.021, and 12.2 (SE 2) ms; p<0.001, respectively). During follow-up, a QRS widening 1.1(1.3) ms/year (p<0.001) in both groups was observed. In patients with a preoperative QRS ⩾ 180 ms, no significant difference was observed in the number of patients reaching the composite end point compared with patients with a preoperative QRS of 150-180 ms (25% vs 7%; p = 0.08). However, the former more often reached QRS ⩾180 ms again after surgery compared with the latter (53% vs 13%; p=0.02, respectively). None of the patients with a preoperative QRS ⩾ 180 ms died during follow-up. Conclusion: In our study, we observed a decrease in QRS duration directly after surgery, followed by a steady increase, in patients with a preoperative QRS >150 ms. The beneficial effect of pulmonary valve replacement on QRS duration was transient. The risk of developing ventricular arrhythmias after surgery was substantial when preoperative QRS was ⩾180 ms, but mortality remained low. [ABSTRACT FROM AUTHOR]
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- 2007
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14. Individualised prediction of pulmonary homograft durability in tetralogy of Fallot.
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Ee Ling Heng, Gatzoulis, Michael A., Babu-Narayan, Sonya V., Bokma, Jouke P, Winter, Michiel M, Oosterhof, Thomas, Vliegen, Hubert W, van Dijk, Arie P, Hazekamp, Mark G, Koolbergen, Dave R, Groenink, Maarten, Mulder, Barbara Jm, Bouma, Berto J, and Mulder, Barbara J M
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PULMONARY artery ,PULMONARY valve ,AGE distribution ,HEART ventricle diseases ,CARDIOVASCULAR surgery ,ECHOCARDIOGRAPHY ,HOMOGRAFTS ,RIGHT heart ventricle ,HEALTH outcome assessment ,COMPLICATIONS of prosthesis ,REOPERATION ,RISK assessment ,SURGICAL complications ,TETRALOGY of Fallot ,PROPORTIONAL hazards models ,RETROSPECTIVE studies ,DIAGNOSIS ,SURGERY - Abstract
Background: In patients with repaired tetralogy of Fallot (rTOF), multiple reoperations or percutaneous interventions after pulmonary valve replacement (PVR) may be necessary due to limited homograft durability. However, data to guide individualised prediction of homograft durability remain scarce. The aim of this study was to provide risk models for RV to pulmonary artery homograft durability.Methods: This retrospective multicentre study included consecutive patients with rTOF who had undergone PVR at an age of >12 years. Homograft dysfunction was defined as at least moderate pulmonary regurgitation (PR) or pulmonary stenosis (PS) (pressure gradient ≥36 mm Hg) as assessed by echocardiography. Reintervention was defined as percutaneous intervention or redo-PVR.Results: A total of 153 patients with rTOF were included (62% male, mean age at PVR 31±11 years, pulmonary homograft 96%, follow-up 9.6 years (IQR 5.9, 13.3)). Average freedom from homograft dysfunction and reintervention after 10 years was 74% and 89%, respectively. In multivariable Cox proportional hazards analysis, postoperative PS ≥20 mm Hg (HR 6.52, 95% CI 3.09 to 13.7), postoperative PR ≥ grade 1 (HR 3.13, 95% CI 1.45 to 6.74) and age at PVR <18 years (HR 3.52, 95% CI 1.64 to 7.53) were independently predictive for homograft dysfunction. In patients without any risk factor, 10-year freedom from homograft dysfunction and reintervention was excellent (91% and 96%, respectively) in contrast to patients with ≥2 risk factors (25% and 73%, respectively).Conclusions: Individualised prediction of homograft durability in patients with rTOF can be guided by early postoperative echocardiography. In adult patients without early postoperative PS or PR, homograft dysfunction and reintervention are unlikely to occur within 10 years, and follow-up may be less stringent. [ABSTRACT FROM AUTHOR]- Published
- 2015
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15. QRS fragmentation is superior to QRS duration in predicting mortality in adults with tetralogy of Fallot.
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Bokma, Jouke P, Winter, Michiel M, Vehmeijer, Jim T, Vliegen, Hubert W, van Dijk, Arie P, van Melle, Joost P, Meijboom, Folkert J, Post, Martijn C, Zwinderman, Aeilko H, Mulder, Barbara J M, and Bouma, Berto J
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ARRHYTHMIA diagnosis ,ACTION potentials ,ARRHYTHMIA ,CHI-squared test ,COMPARATIVE studies ,CAUSES of death ,ELECTROCARDIOGRAPHY ,HEART beat ,HEART conduction system ,RESEARCH methodology ,MEDICAL cooperation ,MULTIVARIATE analysis ,PROGNOSIS ,RESEARCH ,RISK assessment ,TETRALOGY of Fallot ,TIME ,EVALUATION research ,PREDICTIVE tests ,ACQUISITION of data ,PROPORTIONAL hazards models ,RETROSPECTIVE studies ,KAPLAN-Meier estimator ,DISEASE complications ,DIAGNOSIS - Abstract
Background: Although QRS duration >180 ms has prognostic value in adults with tetralogy of Fallot (TOF), its sensitivity to predict mortality is low. Fragmented QRS complexes, a simple measurement on ECG, are related to myocardial fibrosis and dysfunction in patients with TOF. Our objective was to determine whether QRS fragmentation predicts major outcomes in TOF.Methods: This multicentre study included adult patients with TOF from a prospective registry. Notches in the QRS complex in ≥2 contiguous leads on a 12-lead ECG, not related to bundle branch block, were defined as QRS fragmentation, which was classified as none, moderate (≤4 leads) or severe (≥5 leads). The primary and secondary outcomes were all-cause mortality and clinical ventricular arrhythmia, respectively.Results: A total of 794 adult patients with TOF (median age 27 years, 55% male; 52% no QRS fragmentation, 32% moderate, 16% severe) were included. During long-term (median 10.4 years) follow-up, 46 (6%) patients died and 35 (4%) patients had ventricular arrhythmias. Overall, 10-year survival was 98% in patients without fragmented QRS complexes, 93% in patients with moderate QRS fragmentation and 81% in patients with severe QRS fragmentation. In multivariable Cox hazards regression analysis, extent of QRS fragmentation (HR: 2.24/class, 95% CI 1.48 to 3.40, p<0.001) remained independently predictive for mortality, whereas QRS duration was not predictive (p=0.85). The extent of QRS fragmentation was also independently predictive for ventricular arrhythmia (HR: 2.00/class, 95% CI 1.26 to 3.16, p=0.003).Conclusions: The extent of QRS fragmentation is superior to QRS duration in predicting mortality in adult patients with TOF and may be used in risk stratification. [ABSTRACT FROM AUTHOR]- Published
- 2016
- Full Text
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