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Start Over Author "Mamatha Pasnoor" Publisher bmj publishing group
2 results on '"Mamatha Pasnoor"'

1. Epidemiological evidence for a hereditary contribution to myasthenia gravis: a retrospective cohort study of patients from North America

Author

Joel Oger, Joshua D Green, Bryan J Traynor, Richard J Barohn, Michael Benatar, Emanuela Bartoccion, Derrick Blackmore, Manisha Chopra, Andrea Corse, Mazen M Dimachkie, Amelia Evoli, Julaine Florence, Miriam Freimer, James F Howard, Theresa Jiwa, Henry J Kaminski, John T Kissel, Wilma J Koopman, Bernadette Lipscomb, Michelanglo Maestri, Mariapaola Marino, Janice M Massey, April McVey, Michelle M Mezei, Michael W Nicolle, Robert M Pascuzzi, Mamatha Pasnoor, Alan Pestronk, Carlo Provenzano, Roberta Ricciardi, David P Richman, Julie Rowin, Donald B Sanders, Zaeem Siddiqi, Aimee Soloway, Gil I Wolfe, Charlie Wulf, and Daniel B Drachman

Subjects
Medicine
Abstract

Objectives To approximate the rate of familial myasthenia gravis and the coexistence of other autoimmune disorders in the patients and their families.Design Retrospective cohort study.Setting Clinics across North America.Participants The study included 1032 patients diagnosed with acetylcholine receptor antibody (AChR)-positive myasthenia gravis.Methods Phenotype information of 1032 patients diagnosed with AChR-positive myasthenia gravis was obtained from clinics at 14 centres across North America between January 2010 and January 2011. A critical review of the epidemiological literature on the familial rate of myasthenia gravis was also performed.Results Among 1032 patients, 58 (5.6%) reported a family history of myasthenia gravis. A history of autoimmune diseases was present in 26.6% of patients and in 28.4% of their family members.Discussion The familial rate of myasthenia gravis was higher than would be expected for a sporadic disease. Furthermore, a high proportion of patients had a personal or family history of autoimmune disease. Taken together, these findings suggest a genetic contribution to the pathogenesis of myasthenia gravis.

Published
2020
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2. Epidemiological evidence for a hereditary contribution to myasthenia gravis: a retrospective cohort study of patients from North America

Author

Zaeem A. Siddiqi, Robert M. Pascuzzi, Mazen M. Dimachkie, David P. Richman, Richard J. Barohn, Srikanth Muppidi, Michael Benatar, Julaine Florence, M Marino, Michelanglo Maestri, Vinay Chaudhry, Theresa Jiwa, Joshua D. Green, Roberta Ricciardi, Wilma J. Koopman, Joel Oger, Bernadette Lipscomb, Daniel B. Drachman, Manisha Chopra, Amelia Evoli, Derrick Blackmore, Julie Rowin, Gil I. Wolfe, Donald B. Sanders, Michelle M. Mezei, Carlo Provenzano, Henry J. Kaminski, Andrea M. Corse, Aimee Soloway, John T. Kissel, Alan Pestronk, Janice M. Massey, Emanuela Bartoccion, Miriam Freimer, Michael W. Nicolle, Charlie Wulf, April McVey, James F. Howard, Mamatha Pasnoor, and Bryan J. Traynor

Subjects
medicine.medical_specialty, Pediatrics, Neuromuscular disease, Neurology, Clinical Sciences, Neurogenetics, Neurodegenerative, Autoimmune Disease, Settore MED/05 - PATOLOGIA CLINICA, Rare Diseases, Clinical Research, immune system diseases, Epidemiology, Myasthenia Gravis, Receptors, medicine, Genetics, Humans, 2.1 Biological and endogenous factors, Receptors, Cholinergic, genetics, Family history, Aetiology, neurogenetics, Cholinergic, Autoantibodies, Retrospective Studies, Autoimmune disease, Other Medical and Health Sciences, business.industry, neurology, Neurosciences, Retrospective cohort study, General Medicine, neuromuscular disease, medicine.disease, Myasthenia gravis, nervous system diseases, North America, Public Health and Health Services, Medicine, epidemiology, business
Abstract

ObjectivesTo approximate the rate of familial myasthenia gravis and the coexistence of other autoimmune disorders in the patients and their families.DesignRetrospective cohort study.SettingClinics across North America.ParticipantsThe study included 1032 patients diagnosed with acetylcholine receptor antibody (AChR)-positive myasthenia gravis.MethodsPhenotype information of 1032 patients diagnosed with AChR-positive myasthenia gravis was obtained from clinics at 14 centres across North America between January 2010 and January 2011. A critical review of the epidemiological literature on the familial rate of myasthenia gravis was also performed.ResultsAmong 1032 patients, 58 (5.6%) reported a family history of myasthenia gravis. A history of autoimmune diseases was present in 26.6% of patients and in 28.4% of their family members.DiscussionThe familial rate of myasthenia gravis was higher than would be expected for a sporadic disease. Furthermore, a high proportion of patients had a personal or family history of autoimmune disease. Taken together, these findings suggest a genetic contribution to the pathogenesis of myasthenia gravis.

Published
2020

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