1. Can myocardial work indices contribute to the exploration of patients with cardiac amyloidosis?
- Author
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Didier Carrié, Eve Cariou, Pauline Fournier, Michel Galinier, Olivier Lairez, Aénora Roger-Rollé, Khailène Rguez, Yoan Lavie-Badie, Virginie Blanchard, and Jérôme Roncalli
- Subjects
Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background Cardiac amyloidosis (CA) is a life-threatening restrictive cardiomyopathy. Identifying patients with a poor prognosis is essential to ensure appropriate care. The aim of this study was to compare myocardial work (MW) indices with standard echocardiographic parameters in predicting mortality among patients with CA.Methods Clinical, biological and transthoracic echocardiographic parameters were retrospectively compared among 118 patients with CA. Global work index (GWI) was calculated as the area of left ventricular pressure–strain loop. Global work efficiency (GWE) was defined as percentage ratio of constructive work to sum of constructive and wasted works. Sixty-one (52%) patients performed a cardiopulmonary exercise.Results GWI, GWE, global longitudinal strain (GLS), left ventricular ejection fraction (LVEF) and myocardial contraction fraction (MCF) were correlated with N-terminal prohormone brain natriuretic peptide (R=−0.518, R=−0.383, R=−0.553, R=−0.382 and R=−0.336, respectively; p
- Published
- 2020
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