Search

Your search keyword '"Bortone, Alessandro Santo"' showing total 4 results
Start Over Author "Bortone, Alessandro Santo" Publisher bmj publishing group
4 results on '"Bortone, Alessandro Santo"'

1. Symptoms, disease severity and treatment of adults with a new diagnosis of severe aortic stenosis

Author

Frey, Norbert, Steeds, Richard Paul, Rudolph, Tanja K., Thambyrajah, Jeetendra, Serra, Antonio, Schulz, Eberhard, Maly, Jiri, Aiello, Marco, Lloyd, Guy, Bortone, Alessandro Santo, Hauptmann, Karl Eugen, Clerici, Alberto, Delle Karth, Georg, Rieber, Johannes, Indorfi, Ciro, Mancone, Massimo, Belle, Loic, Lauten, Alexander, Arnold, Martin, Bouma, Berto J., Lutz, Matthias, Pohlmann, Christiane, Kurucova, Jana, Thoenes, Martin, Bramlage, Peter, Messika-Zeitoun, David, Cardiology, ACS - Heart failure & arrhythmias, and ACS - Pulmonary hypertension & thrombosis

Subjects
Male, Comorbidity, Risk Assessment, Severity of Illness Index, Ventricular Function, Left, aortic stenosis, surgical aortic valve replacement, symptoms, transcatheter aortic valve replacement, age factors, aged, aged, 80 and over, aortic valve, aortic valve stenosis, asymptomatic diseases, comorbidity, cross-sectional studies, europe, female, hemodynamics, humans, male, predictive value of tests, prognosis, prospective studies, registries, risk assessment, risk factors, severity of illness index, ventricular function, left, echocardiography, left, Predictive Value of Tests, Risk Factors, 80 and over, Humans, Prospective Studies, Registries, Aged, Aged, 80 and over, Age Factors, Hemodynamics, Aortic Valve Stenosis, Prognosis, Europe, Cross-Sectional Studies, Echocardiography, Aortic Valve, Asymptomatic Diseases, ventricular function, Female
Abstract

Objective Contemporary data on patients with previously undiagnosed severe aortic stenosis (AS) are scarce. We aimed to address this gap by gathering data from consecutive patients diagnosed with severe AS on echocardiography. Methods This was a prospective, multicentre, multinational, registry in 23 tertiary care hospitals across 9 European countries. Patients with a diagnosis of severe AS were included using echocardiography (aortic valve area (AVA) 4 m/s and/or mean transvalvular gradient >40 mm Hg). Results The 2171 participants had a mean age of 77.9 years and 48.0% were female. The mean AVA was 0.73 cm 2, V max 4.3 m/s and mean gradient 47.1 mm Hg; 62.1% had left ventricular hypertrophy and 27.3% an ejection fraction (EF)

Published
2019

2. IMPULSE: the impact of gender on the presentation and management of aortic stenosis across Europe.

Author

Steeds, Richard Paul, Messika-Zeitoun, David, Thambyrajah, Jeetendra, Serra, Antonio, Schulz, Eberhard, Maly, Jiri, Aiello, Marco, Rudolph, Tanja K., Lloyd, Guy, Bortone, Alessandro Santo, Clerici, Alberto, Delle-Karth, Georg, Rieber, Johannes, Indolfi, Ciro, Mancone, Massimo, Belle, Loic, Lauten, Alexander, Arnold, Martin, Bouma, Berto J., and Lutz, Matthias

Published
2021
Full Text
View/download PDF

4. Management of patients with severe aortic stenosis in the TAVI-era: how recent recommendations are translated into clinical practice.

Author

Lauten A, Rudolph TK, Messika-Zeitoun D, Thambyrajah J, Serra A, Schulz E, Frey N, Maly J, Aiello M, Lloyd G, Bortone AS, Clerici A, Delle-Karth G, Rieber J, Indolfi C, Mancone M, Belle L, Arnold M, Bouma BJ, Lutz M, Deutsch C, Kurucova J, Thoenes M, Bramlage P, and Steeds RP

Subjects
Aged, Aortic Valve Stenosis diagnosis, Echocardiography, Female, Follow-Up Studies, Humans, Male, Prospective Studies, Severity of Illness Index, Aortic Valve Stenosis surgery, Disease Management, Practice Guidelines as Topic, Quality of Health Care, Transcatheter Aortic Valve Replacement standards
Abstract

Objective: Approximately 3.4% of adults aged >75 years suffer from aortic stenosis (AS). Guideline indications for aortic valve replacement (AVR) distinguish between patients with symptomatic and asymptomatic severe AS. The present analysis aims to assess contemporary practice in the treatment of severe AS across Europe and identify characteristics associated with treatment decisions, namely denial of AVR in symptomatic patients and assignment of asymptomatic patients to AVR., Methods: Participants of the prospective, multinational IMPULSE database of patients with severe AS were grouped according to AS symptoms, and stratified into subgroups based on assignment to/denial of AVR., Results: Of 1608 symptomatic patients, 23.8% did not undergo AVR and underwent medical treatment. Denial was independently associated with multiple factors, including severe frailty (p=0.024); mitral (p=0.002) or tricuspid (p=0.004) regurgitation grade III/IV, and the presence of renal impairment (p=0.017). Of 392 asymptomatic patients, 86.5% had no prespecified indication for AVR. Regardless, 36.3% were assigned to valve replacement. Those with an indexed aortic valve area (AVA; p=0.045) or left ventricular ejection fraction (LVEF; p<0.001) below the study median; or with a left ventricular end systolic diameter above the study median (p=0.007) were more likely to be assigned to AVR., Conclusions: There may be considerable discrepancies between guideline-based recommendations and clinical practice decision-making in the treatment of AS. It appears that guidelines may not fully capture the complete clinical spectrum of patients with AS. Thus, there is a need to find ways to increase their acceptance and the rate of adoption., Competing Interests: Competing interests: Peter Bramlage received research funding from Edwards Lifesciences, Nyon, Switzerland. Norbert Frey, Rick Steeds and David Messika-Zeitoun have received honoraria for advisory board meetings and Tanja Rudolph speakers’ honoraria from Edwards Lifesciences. The institutions of these three and those of the remaining authors representing study centres have received funding for employing a study nurse., (© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results