1. Point-of-care ultrasound for tuberculosis diagnosis in children: a Médecins Sans Frontières cross-sectional study in Guinea-Bissau
- Author
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Laura Moreto-Planas, Sakib Burza, Raman Mahajan, Sabine Bélard, Candida Medina, María José Sagrado, Jonathan Gallo, Evelize Biague, Ramiro Gonçalves, Pablo Nuozzi, Merce Rocaspana, Jamila Vieira Fonseca, Miguel Camará, Adi Nadimpalli, Beatriz Alonso, Augusto E Llosa, Lotje Heuvelings, Israel Molina, Lisa C Ruby, and Erin Stratta
- Subjects
Medicine - Abstract
Objective Description of tuberculosis (TB)-focused point-of-care ultrasound (POCUS) findings for children with presumptive TB.Design Cross-sectional study (July 2019 to April 2020).Setting Simão Mendes hospital in Bissau, a setting with high TB, HIV, and malnutrition burdens.Participants Patients aged between 6 months and 15 years with presumptive TB.Interventions Participants underwent clinical, laboratory and unblinded clinician-performed POCUS assessments, to assess subpleural nodules (SUNs), lung consolidation, pleural and pericardial effusion, abdominal lymphadenopathy, focal splenic and hepatic lesions and ascites. Presence of any sign prompted a POCUS positive result. Ultrasound images and clips were evaluated by expert reviewers and, in case of discordance, by a second reviewer. Children were categorised as confirmed TB (microbiological diagnosis), unconfirmed TB (clinical diagnosis) or unlikely TB. Ultrasound findings were analysed per TB category and risk factor: HIV co-infection, malnutrition and age.Results A total of 139 children were enrolled, with 62 (45%) women and 55 (40%) aged
- Published
- 2023
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